Effect of NK cell receptor genetic variation on allogeneic stem cell transplantation outcome and in vitro NK cell cytotoxicity

Effect of NK cell receptor genetic variation on allogeneic stem cell transplantation outcome and in vitro NK cell cytotoxicity

Abstract Natural killer (NK) cells recognize and may kill malignant cells via their cell surface receptors. Killer cell immunoglobulin-like receptor (KIR) genotypes of donors have been reported to adjust the risk of relapse after allogeneic stem cell transplantation (HSCT), particularly in patients...

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Main Authors: Julia Nihtilä, Leena Penna, Urpu Salmenniemi, Maija Itälä-Remes, Rachel E. Crossland, David Gallardo, Katarzyna Bogunia-Kubik, Piotr Lacina, Maria Bieniaszewska, Sebastian Giebel, Katariina Karjalainen, Farhana Jahan, Erja Kerkelä, Kati Hyvärinen, Satu Koskela, Jarmo Ritari, Jukka Partanen
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-78619-5
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