Increased spindle-related brain activation in right middle temporal gyrus during N2 than N3 among healthy sleepers: Initial discovery and independent sample replication

Increased spindle-related brain activation in right middle temporal gyrus during N2 than N3 among healthy sleepers: Initial discovery and independent sample replication

The association between spindle metrics and sleep architecture differs during N2 vs. N3 sleep, the underlying neural mechanism is not clearly illustrated. Here, we tested the discrepancy in spindle-related brain activation between N2 and N3 within healthy college students (dataset 1: n = 27, 59 % fe...

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Main Authors: Yan Shao, Yupeng Guo, Yun Chen, Guangyuan Zou, Jie Chen, Xuejiao Gao, Panpan Lu, Yujie Tong, Yuezhen Li, Ping Yao, Jiayi Liu, Shuqin Zhou, Jing Xu, Jia-Hong Gao, Qihong Zou, Hongqiang Sun
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:NeuroImage
Subjects:
Sleep spindles
Brain activation
N2
Sleep duration
EEG-fMRI
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811924004737
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Summary:The association between spindle metrics and sleep architecture differs during N2 vs. N3 sleep, the underlying neural mechanism is not clearly illustrated. Here, we tested the discrepancy in spindle-related brain activation between N2 and N3 within healthy college students (dataset 1: n = 27, 59 % females, median age 23 years), using simultaneous electroencephalography-functional magnetic resonance imaging (EEG-fMRI). To assess the replicability of the finding, we repeated the analysis among normal adults (independent dataset 2: n = 30, 50 % females, median age 32 years). The finding from dataset 1 indicated significantly increased blood-oxygen level-dependent signal in the right middle temporal gyrus during N2 compared with N3, which was well replicated in dataset 2. Furthermore, correlation analysis was performed to explore the association between this spindle-related brain activation and N2, N3 sleep duration during EEG-fMRI. We conducted the correlation analysis in N2 and N3, respectively. The negative association between spindle-related brain activation in the right middle temporal gyrus and sleep duration was only observed in N2. Our findings emphasize the unique role of spindle-related brain activation in the right middle temporal gyrus during N2 in shortening N2 sleep duration.
ISSN:1095-9572

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