Decursinol angelate relieves inflammatory bowel disease by inhibiting the ROS/TXNIP/NLRP3 pathway and pyroptosis

Decursinol angelate relieves inflammatory bowel disease by inhibiting the ROS/TXNIP/NLRP3 pathway and pyroptosis

IntroductionDespite evidence of the efficacy of decursinol angelate (DA), a prescription medication derived farom traditional Chinese medicine, in alleviating inflammatory bowel disease (IBD), the precise mechanisms behind its action remain unclear.MethodsLipopolysaccharides (LPS) and dextran sodium...

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Bibliographic Details
Main Authors: Yudi Wang, Jiamin Wang, Yonghu Chen, Xuezheng Li, Zhe Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
angelica gigas nakai
NLRP3 inflammasome
IBD
pyroptosis
decursinol angelate
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1520040/full
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