Serum amyloid A1 (SAA1) protein in human colostrum
Proteins of the serum amyloid A (SAA) family have been remarkably conserved in evolution. Their biologic function(s) are not fully defined but they are likely to be a part of primordial host defense. We have detected a ∼ 12‐kDa protein reacting with antibodies against serum amyloid A (SAA) in human...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-03-01
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| Series: | FEBS Open Bio |
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| Online Access: | https://doi.org/10.1002/2211-5463.12383 |
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| _version_ | 1846108038152323072 |
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| author | George H. Sack Jr Natasha Zachara Nadine Rosenblum C. Conover Talbot Jr Simion Kreimer Robert Cole Thomas L. McDonald |
| author_facet | George H. Sack Jr Natasha Zachara Nadine Rosenblum C. Conover Talbot Jr Simion Kreimer Robert Cole Thomas L. McDonald |
| author_sort | George H. Sack Jr |
| collection | DOAJ |
| description | Proteins of the serum amyloid A (SAA) family have been remarkably conserved in evolution. Their biologic function(s) are not fully defined but they are likely to be a part of primordial host defense. We have detected a ∼ 12‐kDa protein reacting with antibodies against serum amyloid A (SAA) in human colostrum by western blotting. Mass spectrometry identified the reactive species as SAA1, previously identified as a prominent member of the acute‐phase response in serum. Our finding SAA1 in human colostrum contrasts with bovine, caprine and ovine colostrum where a species corresponding to putative SAA3 is uniformly present. SAA1 protein in human colostrum presumably contributes to neonatal protection. |
| format | Article |
| id | doaj-art-ed38f28fe8264c4eb8de67b3b53797d4 |
| institution | Kabale University |
| issn | 2211-5463 |
| language | English |
| publishDate | 2018-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj-art-ed38f28fe8264c4eb8de67b3b53797d42024-12-26T06:31:12ZengWileyFEBS Open Bio2211-54632018-03-018343544110.1002/2211-5463.12383Serum amyloid A1 (SAA1) protein in human colostrumGeorge H. Sack Jr0Natasha Zachara1Nadine Rosenblum2C. Conover Talbot Jr3Simion Kreimer4Robert Cole5Thomas L. McDonald6Department of Biological Chemistry Johns Hopkins University School of Medicine Baltimore MD USADepartment of Biological Chemistry Johns Hopkins University School of Medicine Baltimore MD USADepartment of Obstetrics and Gynecology Johns Hopkins University School of Medicine Baltimore MD USAInstitute for Basic Biomedical Sciences Johns Hopkins University School of Medicine Baltimore MD USAInstitute for Basic Biomedical Sciences Johns Hopkins University School of Medicine Baltimore MD USADepartment of Biological Chemistry Johns Hopkins University School of Medicine Baltimore MD USADepartment of Pathology University of Nebraska Medical Center Omaha NE USAProteins of the serum amyloid A (SAA) family have been remarkably conserved in evolution. Their biologic function(s) are not fully defined but they are likely to be a part of primordial host defense. We have detected a ∼ 12‐kDa protein reacting with antibodies against serum amyloid A (SAA) in human colostrum by western blotting. Mass spectrometry identified the reactive species as SAA1, previously identified as a prominent member of the acute‐phase response in serum. Our finding SAA1 in human colostrum contrasts with bovine, caprine and ovine colostrum where a species corresponding to putative SAA3 is uniformly present. SAA1 protein in human colostrum presumably contributes to neonatal protection.https://doi.org/10.1002/2211-5463.12383acute‐phaseamyloidcolostrumserum amyloid A |
| spellingShingle | George H. Sack Jr Natasha Zachara Nadine Rosenblum C. Conover Talbot Jr Simion Kreimer Robert Cole Thomas L. McDonald Serum amyloid A1 (SAA1) protein in human colostrum FEBS Open Bio acute‐phase amyloid colostrum serum amyloid A |
| title | Serum amyloid A1 (SAA1) protein in human colostrum |
| title_full | Serum amyloid A1 (SAA1) protein in human colostrum |
| title_fullStr | Serum amyloid A1 (SAA1) protein in human colostrum |
| title_full_unstemmed | Serum amyloid A1 (SAA1) protein in human colostrum |
| title_short | Serum amyloid A1 (SAA1) protein in human colostrum |
| title_sort | serum amyloid a1 saa1 protein in human colostrum |
| topic | acute‐phase amyloid colostrum serum amyloid A |
| url | https://doi.org/10.1002/2211-5463.12383 |
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