Association of Statin Therapy with Functional Outcomes and Survival in Intracerebral and Subarachnoid Hemorrhage
<b>Background/Objectives</b>: Intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH) are severe forms of stroke with high morbidity and mortality rates. HMG-CoA reductase inhibitors, commonly referred to as statins, known for their lipid-lowering abilities, also possess pleiotr...
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2025-02-01
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| author | Bahadar S. Srichawla Daksha Gopal Majaz Moonis |
| author_facet | Bahadar S. Srichawla Daksha Gopal Majaz Moonis |
| author_sort | Bahadar S. Srichawla |
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| description | <b>Background/Objectives</b>: Intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH) are severe forms of stroke with high morbidity and mortality rates. HMG-CoA reductase inhibitors, commonly referred to as statins, known for their lipid-lowering abilities, also possess pleiotropic properties, including anti-inflammatory and neuroprotective effects. We aimed to evaluate the impact of statin therapy on the functional outcomes and survival in patients with ICH and SAH. <b>Methods</b>: This retrospective cohort study analyzed data from the Get With The Guidelines (GWTG) stroke registry at a tertiary care center, including patients diagnosed with ICH or SAH between January 2008 and June 2022. Patients were categorized based on prior initiation of statin therapy: no statin, low-intensity statin, or high-intensity statin. The primary outcome was the Modified Rankin Scale (mRS) score at discharge, dichotomized to good (0–2) and poor (3–6) outcomes. A multivariate logistic regression model controlled for age, gender, and National Institutes of Health Stroke Scale (NIHSS) score at admission. <b>Results</b>: A total of 663 patients with ICH and 159 patients with SAH were included in the analysis. In the ICH patients, low-intensity statin therapy was associated with significantly higher odds of a good functional outcome (aOR 2.56, 95% CI 1.247–5.246, <i>p</i> = 0.0104), as was high-intensity statin therapy (aOR 2.445, 95% CI 1.313–4.552, <i>p</i> = 0.0048). Among the SAH patients, all 39 deaths occurred in the no statin therapy group. <b>Conclusions</b>: Both low- and high-intensity statin therapy are associated with improved functional outcomes in ICH and may offer a survival benefit in SAH. These findings highlight the potential neuroprotective role of statins in hemorrhagic stroke. Further prospective studies and randomized controlled trials are needed to confirm these observations and to clarify the optimal use of statins in this patient population. |
| format | Article |
| id | doaj-art-ed2fcea56b9f4d2a828e3fb8d9ab77be |
| institution | OA Journals |
| issn | 2035-8377 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neurology International |
| spelling | doaj-art-ed2fcea56b9f4d2a828e3fb8d9ab77be2025-08-20T02:01:24ZengMDPI AGNeurology International2035-83772025-02-011722710.3390/neurolint17020027Association of Statin Therapy with Functional Outcomes and Survival in Intracerebral and Subarachnoid HemorrhageBahadar S. Srichawla0Daksha Gopal1Majaz Moonis2Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USADepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USADepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA<b>Background/Objectives</b>: Intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH) are severe forms of stroke with high morbidity and mortality rates. HMG-CoA reductase inhibitors, commonly referred to as statins, known for their lipid-lowering abilities, also possess pleiotropic properties, including anti-inflammatory and neuroprotective effects. We aimed to evaluate the impact of statin therapy on the functional outcomes and survival in patients with ICH and SAH. <b>Methods</b>: This retrospective cohort study analyzed data from the Get With The Guidelines (GWTG) stroke registry at a tertiary care center, including patients diagnosed with ICH or SAH between January 2008 and June 2022. Patients were categorized based on prior initiation of statin therapy: no statin, low-intensity statin, or high-intensity statin. The primary outcome was the Modified Rankin Scale (mRS) score at discharge, dichotomized to good (0–2) and poor (3–6) outcomes. A multivariate logistic regression model controlled for age, gender, and National Institutes of Health Stroke Scale (NIHSS) score at admission. <b>Results</b>: A total of 663 patients with ICH and 159 patients with SAH were included in the analysis. In the ICH patients, low-intensity statin therapy was associated with significantly higher odds of a good functional outcome (aOR 2.56, 95% CI 1.247–5.246, <i>p</i> = 0.0104), as was high-intensity statin therapy (aOR 2.445, 95% CI 1.313–4.552, <i>p</i> = 0.0048). Among the SAH patients, all 39 deaths occurred in the no statin therapy group. <b>Conclusions</b>: Both low- and high-intensity statin therapy are associated with improved functional outcomes in ICH and may offer a survival benefit in SAH. These findings highlight the potential neuroprotective role of statins in hemorrhagic stroke. Further prospective studies and randomized controlled trials are needed to confirm these observations and to clarify the optimal use of statins in this patient population.https://www.mdpi.com/2035-8377/17/2/27intracerebral hemorrhagesubarachnoid hemorrhagestrokestatinsHMG-CoA reductase |
| spellingShingle | Bahadar S. Srichawla Daksha Gopal Majaz Moonis Association of Statin Therapy with Functional Outcomes and Survival in Intracerebral and Subarachnoid Hemorrhage Neurology International intracerebral hemorrhage subarachnoid hemorrhage stroke statins HMG-CoA reductase |
| title | Association of Statin Therapy with Functional Outcomes and Survival in Intracerebral and Subarachnoid Hemorrhage |
| title_full | Association of Statin Therapy with Functional Outcomes and Survival in Intracerebral and Subarachnoid Hemorrhage |
| title_fullStr | Association of Statin Therapy with Functional Outcomes and Survival in Intracerebral and Subarachnoid Hemorrhage |
| title_full_unstemmed | Association of Statin Therapy with Functional Outcomes and Survival in Intracerebral and Subarachnoid Hemorrhage |
| title_short | Association of Statin Therapy with Functional Outcomes and Survival in Intracerebral and Subarachnoid Hemorrhage |
| title_sort | association of statin therapy with functional outcomes and survival in intracerebral and subarachnoid hemorrhage |
| topic | intracerebral hemorrhage subarachnoid hemorrhage stroke statins HMG-CoA reductase |
| url | https://www.mdpi.com/2035-8377/17/2/27 |
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