Targeting Ser78 phosphorylation of Hsp27 achieves potent antiviral effects against enterovirus A71 infection

Targeting Ser78 phosphorylation of Hsp27 achieves potent antiviral effects against enterovirus A71 infection

A positive-sense (+) single-stranded RNA (ssRNA) virus (e.g. enterovirus A71, EV-A71) depends on viral polypeptide translation for initiation of virus replication after entry. We reported that EV-A71 hijacks Hsp27 to induce hnRNP A1 cytosol redistribution to initiate viral protein translation, but t...

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Bibliographic Details
Main Authors: Mandi Wu, Qianya Wan, Xuelian Dan, Yiran Wang, Peiran Chen, Cien Chen, Yichen Li, Xi Yao, Ming-Liang He
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Emerging Microbes and Infections
Subjects:
Hsp27
enterovirus A71
antiviral
phosphorylation
hnRNP A1 translocation
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2024.2368221
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