Bibliometric analysis of metformin as an immunomodulator (2013–2024)
BackgroundMetformin, the frontline treatment for diabetes, has considerable potential as an immunomodulator; however, detailed bibliometric analyses on this subject are limited.MethodsThis study extracted 640 relevant articles from the Web of Science (WOS) Core Collection and conducted visual analys...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1526481/full |
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| author | Tongyi Zhou Yunfeng Yu Liu Li Xiu Liu Xiu Liu Qin Xiang Rong Yu Rong Yu |
| author_facet | Tongyi Zhou Yunfeng Yu Liu Li Xiu Liu Xiu Liu Qin Xiang Rong Yu Rong Yu |
| author_sort | Tongyi Zhou |
| collection | DOAJ |
| description | BackgroundMetformin, the frontline treatment for diabetes, has considerable potential as an immunomodulator; however, detailed bibliometric analyses on this subject are limited.MethodsThis study extracted 640 relevant articles from the Web of Science (WOS) Core Collection and conducted visual analyses using Microsoft Excel, VOSviewer, and CiteSpace.ResultsThe findings showed that research on the immunomodulatory function of metformin has grown steadily since 2017, with China and the United States being the leading contributors. These studies have mostly been published in journals such as the International Journal of Molecular Sciences, Cancers, Frontiers in Immunology, and Scientific Reports. Keyword co-occurrence analysis highlighted metformin’s role as an immunomodulator, particularly in the context of the tumor immune microenvironment, immunosuppressive checkpoints, and metformin derivatives. Recent research has highlighted metformin’s application in aging, autoimmune diseases, COVID-19, and tuberculosis. Additionally, its role in regulating inflammation and gut microbiota is also being investigated.ConclusionOverall, the immunomodulatory effects of metformin were investigated in anti-tumor, antiviral, anti-aging, and autoimmune disease research. This highlights the scope of metformin use in these fields, while also significantly enhancing its clinical value as a repurposed drug. |
| format | Article |
| id | doaj-art-ed25d1aad2e04b14b5da7218f5600b9e |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-ed25d1aad2e04b14b5da7218f5600b9e2025-01-08T06:11:51ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15264811526481Bibliometric analysis of metformin as an immunomodulator (2013–2024)Tongyi Zhou0Yunfeng Yu1Liu Li2Xiu Liu3Xiu Liu4Qin Xiang5Rong Yu6Rong Yu7School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, ChinaSchool of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, ChinaSchool of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, ChinaSchool of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, ChinaHunan Key Laboratory of Traditional Chinese Medicine Prescription and Syndromes Translational Medicine, Hunan University of Chinese Medicine, Changsha, ChinaSchool of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, ChinaSchool of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, ChinaHunan Key Laboratory of Traditional Chinese Medicine Prescription and Syndromes Translational Medicine, Hunan University of Chinese Medicine, Changsha, ChinaBackgroundMetformin, the frontline treatment for diabetes, has considerable potential as an immunomodulator; however, detailed bibliometric analyses on this subject are limited.MethodsThis study extracted 640 relevant articles from the Web of Science (WOS) Core Collection and conducted visual analyses using Microsoft Excel, VOSviewer, and CiteSpace.ResultsThe findings showed that research on the immunomodulatory function of metformin has grown steadily since 2017, with China and the United States being the leading contributors. These studies have mostly been published in journals such as the International Journal of Molecular Sciences, Cancers, Frontiers in Immunology, and Scientific Reports. Keyword co-occurrence analysis highlighted metformin’s role as an immunomodulator, particularly in the context of the tumor immune microenvironment, immunosuppressive checkpoints, and metformin derivatives. Recent research has highlighted metformin’s application in aging, autoimmune diseases, COVID-19, and tuberculosis. Additionally, its role in regulating inflammation and gut microbiota is also being investigated.ConclusionOverall, the immunomodulatory effects of metformin were investigated in anti-tumor, antiviral, anti-aging, and autoimmune disease research. This highlights the scope of metformin use in these fields, while also significantly enhancing its clinical value as a repurposed drug.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1526481/fullmetforminimmunomodulatortumor immune microenvironmentimmune checkpoint inhibitionaginginflammation |
| spellingShingle | Tongyi Zhou Yunfeng Yu Liu Li Xiu Liu Xiu Liu Qin Xiang Rong Yu Rong Yu Bibliometric analysis of metformin as an immunomodulator (2013–2024) Frontiers in Immunology metformin immunomodulator tumor immune microenvironment immune checkpoint inhibition aging inflammation |
| title | Bibliometric analysis of metformin as an immunomodulator (2013–2024) |
| title_full | Bibliometric analysis of metformin as an immunomodulator (2013–2024) |
| title_fullStr | Bibliometric analysis of metformin as an immunomodulator (2013–2024) |
| title_full_unstemmed | Bibliometric analysis of metformin as an immunomodulator (2013–2024) |
| title_short | Bibliometric analysis of metformin as an immunomodulator (2013–2024) |
| title_sort | bibliometric analysis of metformin as an immunomodulator 2013 2024 |
| topic | metformin immunomodulator tumor immune microenvironment immune checkpoint inhibition aging inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1526481/full |
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