Decoding the impact of the placebo response in clinical trials for chronic cough
Chronic cough is a prevalent and challenging condition, with limited treatment options available. The interpretation of clinical trial results for antitussive drugs is complicated by the presence of the placebo response, which can confound outcomes and impede regulatory approval. This review aims to...
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2024-10-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/10/5/00335-2024.full |
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| _version_ | 1846170566319407104 |
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| author | Mengru Zhang Bangyu Zhang Alyn H. Morice |
| author_facet | Mengru Zhang Bangyu Zhang Alyn H. Morice |
| author_sort | Mengru Zhang |
| collection | DOAJ |
| description | Chronic cough is a prevalent and challenging condition, with limited treatment options available. The interpretation of clinical trial results for antitussive drugs is complicated by the presence of the placebo response, which can confound outcomes and impede regulatory approval. This review aims to explore the impact of the placebo response on clinical trials for cough medications and elucidate the underlying mechanisms involved. The multifaceted nature of antitussive effects, including pharmacological, psychological/neurobiological and nonspecific effects, is discussed. Additionally, potential solutions to address the placebo response in future cough medication development, such as strategic study design, appropriate choice of end-points and meticulous patient selection, are proposed. More progress to harness this issue is urgently needed. |
| format | Article |
| id | doaj-art-ed1756ac03a643e09a01af9f6b09182c |
| institution | Kabale University |
| issn | 2312-0541 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj-art-ed1756ac03a643e09a01af9f6b09182c2024-11-11T16:33:08ZengEuropean Respiratory SocietyERJ Open Research2312-05412024-10-0110510.1183/23120541.00335-202400335-2024Decoding the impact of the placebo response in clinical trials for chronic coughMengru Zhang0Bangyu Zhang1Alyn H. Morice2 Centre for Clinical Science, Respiratory Medicine, Hull York Medical School, University of Hull, Castle Hill Hospital, Cottingham, UK Clinical Research Center, Department of Pharmacy, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China Centre for Clinical Science, Respiratory Medicine, Hull York Medical School, University of Hull, Castle Hill Hospital, Cottingham, UK Chronic cough is a prevalent and challenging condition, with limited treatment options available. The interpretation of clinical trial results for antitussive drugs is complicated by the presence of the placebo response, which can confound outcomes and impede regulatory approval. This review aims to explore the impact of the placebo response on clinical trials for cough medications and elucidate the underlying mechanisms involved. The multifaceted nature of antitussive effects, including pharmacological, psychological/neurobiological and nonspecific effects, is discussed. Additionally, potential solutions to address the placebo response in future cough medication development, such as strategic study design, appropriate choice of end-points and meticulous patient selection, are proposed. More progress to harness this issue is urgently needed.http://openres.ersjournals.com/content/10/5/00335-2024.full |
| spellingShingle | Mengru Zhang Bangyu Zhang Alyn H. Morice Decoding the impact of the placebo response in clinical trials for chronic cough ERJ Open Research |
| title | Decoding the impact of the placebo response in clinical trials for chronic cough |
| title_full | Decoding the impact of the placebo response in clinical trials for chronic cough |
| title_fullStr | Decoding the impact of the placebo response in clinical trials for chronic cough |
| title_full_unstemmed | Decoding the impact of the placebo response in clinical trials for chronic cough |
| title_short | Decoding the impact of the placebo response in clinical trials for chronic cough |
| title_sort | decoding the impact of the placebo response in clinical trials for chronic cough |
| url | http://openres.ersjournals.com/content/10/5/00335-2024.full |
| work_keys_str_mv | AT mengruzhang decodingtheimpactoftheplaceboresponseinclinicaltrialsforchroniccough AT bangyuzhang decodingtheimpactoftheplaceboresponseinclinicaltrialsforchroniccough AT alynhmorice decodingtheimpactoftheplaceboresponseinclinicaltrialsforchroniccough |