Combining genomics and epidemiology to investigate a zoonotic outbreak of rabies in Romblon Province, Philippines
Abstract Rabies is a viral zoonosis that kills thousands of people annually in low- and middle-income countries across Africa and Asia where domestic dogs are the reservoir. ‘Zero by 30’, the global strategy to end dog-mediated human rabies, promotes a One Health approach underpinned by mass dog vac...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-12-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-54255-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559325826351104 |
|---|---|
| author | Mirava Yuson Criselda T. Bautista Eleanor M. Rees Carlijn Bogaardt Van Denn D. Cruz Rowan Durrant Anna Formstone Daria L. Manalo Duane R. Manzanilla Mikolaj Kundergorski Leilanie Nacion Hannaniah Aloyon Jude Karlo Bolivar Jeromir Bondoc Christina Cobbold Efraim Panganiban Shynie Vee. M. Telmo Jobin Maestro Mary Elizabeth G. Miranda Nai Rui Chng Kirstyn Brunker Katie Hampson |
| author_facet | Mirava Yuson Criselda T. Bautista Eleanor M. Rees Carlijn Bogaardt Van Denn D. Cruz Rowan Durrant Anna Formstone Daria L. Manalo Duane R. Manzanilla Mikolaj Kundergorski Leilanie Nacion Hannaniah Aloyon Jude Karlo Bolivar Jeromir Bondoc Christina Cobbold Efraim Panganiban Shynie Vee. M. Telmo Jobin Maestro Mary Elizabeth G. Miranda Nai Rui Chng Kirstyn Brunker Katie Hampson |
| author_sort | Mirava Yuson |
| collection | DOAJ |
| description | Abstract Rabies is a viral zoonosis that kills thousands of people annually in low- and middle-income countries across Africa and Asia where domestic dogs are the reservoir. ‘Zero by 30’, the global strategy to end dog-mediated human rabies, promotes a One Health approach underpinned by mass dog vaccination, post-exposure vaccination of bite victims, robust surveillance and community engagement. Using Integrated Bite Case Management (IBCM) and whole genome sequencing (WGS), we enhanced rabies surveillance to detect an outbreak in a formerly rabies-free island province in the Philippines. We inferred that the outbreak was seeded by at least three independent human-mediated introductions that were identified as coming from neighbouring rabies-endemic provinces. Considerable local transmission went undetected, and two human deaths occurred within 6 months of outbreak detection. Suspension of routine dog vaccination due to COVID-19 restrictions likely facilitated rabies spread from these introductions. Emergency response, consisting of awareness measures, and ring vaccination, were performed, but swifter and more widespread implementation is needed to contain and eliminate the outbreak and to secure rabies freedom. We conclude that strengthened surveillance making use of new tools such as IBCM, WGS, and rapid diagnostic tests can support One Health in action and progress towards the ‘Zero by 30’ goal. |
| format | Article |
| id | doaj-art-ed06e3da9af04b06afcaca6dd1a15ac6 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-ed06e3da9af04b06afcaca6dd1a15ac62025-01-05T12:35:40ZengNature PortfolioNature Communications2041-17232024-12-0115111410.1038/s41467-024-54255-5Combining genomics and epidemiology to investigate a zoonotic outbreak of rabies in Romblon Province, PhilippinesMirava Yuson0Criselda T. Bautista1Eleanor M. Rees2Carlijn Bogaardt3Van Denn D. Cruz4Rowan Durrant5Anna Formstone6Daria L. Manalo7Duane R. Manzanilla8Mikolaj Kundergorski9Leilanie Nacion10Hannaniah Aloyon11Jude Karlo Bolivar12Jeromir Bondoc13Christina Cobbold14Efraim Panganiban15Shynie Vee. M. Telmo16Jobin Maestro17Mary Elizabeth G. Miranda18Nai Rui Chng19Kirstyn Brunker20Katie Hampson21Boyd Orr Centre for Population and Ecosystem Health, School of Biodiversity, One Health & Veterinary Medicine, College of Medical, Veterinary & Life Sciences, University of GlasgowBoyd Orr Centre for Population and Ecosystem Health, School of Biodiversity, One Health & Veterinary Medicine, College of Medical, Veterinary & Life Sciences, University of GlasgowBoyd Orr Centre for Population and Ecosystem Health, School of Biodiversity, One Health & Veterinary Medicine, College of Medical, Veterinary & Life Sciences, University of GlasgowSchool of Computing Science, College of Science & Engineering, University of GlasgowField Epidemiology Training Programme Alumni Foundation Inc (FETPAFI)Boyd Orr Centre for Population and Ecosystem Health, School of Biodiversity, One Health & Veterinary Medicine, College of Medical, Veterinary & Life Sciences, University of GlasgowBoyd Orr Centre for Population and Ecosystem Health, School of Biodiversity, One Health & Veterinary Medicine, College of Medical, Veterinary & Life Sciences, University of GlasgowResearch Institute for Tropical Medicine (RITM)Field Epidemiology Training Programme Alumni Foundation Inc (FETPAFI)Boyd Orr Centre for Population and Ecosystem Health, School of Biodiversity, One Health & Veterinary Medicine, College of Medical, Veterinary & Life Sciences, University of GlasgowResearch Institute for Tropical Medicine (RITM)Research Institute for Tropical Medicine (RITM)Research Institute for Tropical Medicine (RITM)Research Institute for Tropical Medicine (RITM)School of Mathematics & Statistics, College of Science & Engineering, University of GlasgowResearch Institute for Tropical Medicine (RITM)Regional Animal Disease Diagnostic LaboratoryMunicipal Health OfficeField Epidemiology Training Programme Alumni Foundation Inc (FETPAFI)Boyd Orr Centre for Population and Ecosystem Health, School of Biodiversity, One Health & Veterinary Medicine, College of Medical, Veterinary & Life Sciences, University of GlasgowBoyd Orr Centre for Population and Ecosystem Health, School of Biodiversity, One Health & Veterinary Medicine, College of Medical, Veterinary & Life Sciences, University of GlasgowBoyd Orr Centre for Population and Ecosystem Health, School of Biodiversity, One Health & Veterinary Medicine, College of Medical, Veterinary & Life Sciences, University of GlasgowAbstract Rabies is a viral zoonosis that kills thousands of people annually in low- and middle-income countries across Africa and Asia where domestic dogs are the reservoir. ‘Zero by 30’, the global strategy to end dog-mediated human rabies, promotes a One Health approach underpinned by mass dog vaccination, post-exposure vaccination of bite victims, robust surveillance and community engagement. Using Integrated Bite Case Management (IBCM) and whole genome sequencing (WGS), we enhanced rabies surveillance to detect an outbreak in a formerly rabies-free island province in the Philippines. We inferred that the outbreak was seeded by at least three independent human-mediated introductions that were identified as coming from neighbouring rabies-endemic provinces. Considerable local transmission went undetected, and two human deaths occurred within 6 months of outbreak detection. Suspension of routine dog vaccination due to COVID-19 restrictions likely facilitated rabies spread from these introductions. Emergency response, consisting of awareness measures, and ring vaccination, were performed, but swifter and more widespread implementation is needed to contain and eliminate the outbreak and to secure rabies freedom. We conclude that strengthened surveillance making use of new tools such as IBCM, WGS, and rapid diagnostic tests can support One Health in action and progress towards the ‘Zero by 30’ goal.https://doi.org/10.1038/s41467-024-54255-5 |
| spellingShingle | Mirava Yuson Criselda T. Bautista Eleanor M. Rees Carlijn Bogaardt Van Denn D. Cruz Rowan Durrant Anna Formstone Daria L. Manalo Duane R. Manzanilla Mikolaj Kundergorski Leilanie Nacion Hannaniah Aloyon Jude Karlo Bolivar Jeromir Bondoc Christina Cobbold Efraim Panganiban Shynie Vee. M. Telmo Jobin Maestro Mary Elizabeth G. Miranda Nai Rui Chng Kirstyn Brunker Katie Hampson Combining genomics and epidemiology to investigate a zoonotic outbreak of rabies in Romblon Province, Philippines Nature Communications |
| title | Combining genomics and epidemiology to investigate a zoonotic outbreak of rabies in Romblon Province, Philippines |
| title_full | Combining genomics and epidemiology to investigate a zoonotic outbreak of rabies in Romblon Province, Philippines |
| title_fullStr | Combining genomics and epidemiology to investigate a zoonotic outbreak of rabies in Romblon Province, Philippines |
| title_full_unstemmed | Combining genomics and epidemiology to investigate a zoonotic outbreak of rabies in Romblon Province, Philippines |
| title_short | Combining genomics and epidemiology to investigate a zoonotic outbreak of rabies in Romblon Province, Philippines |
| title_sort | combining genomics and epidemiology to investigate a zoonotic outbreak of rabies in romblon province philippines |
| url | https://doi.org/10.1038/s41467-024-54255-5 |
| work_keys_str_mv | AT miravayuson combininggenomicsandepidemiologytoinvestigateazoonoticoutbreakofrabiesinromblonprovincephilippines AT criseldatbautista combininggenomicsandepidemiologytoinvestigateazoonoticoutbreakofrabiesinromblonprovincephilippines AT eleanormrees combininggenomicsandepidemiologytoinvestigateazoonoticoutbreakofrabiesinromblonprovincephilippines AT carlijnbogaardt combininggenomicsandepidemiologytoinvestigateazoonoticoutbreakofrabiesinromblonprovincephilippines AT vandenndcruz combininggenomicsandepidemiologytoinvestigateazoonoticoutbreakofrabiesinromblonprovincephilippines AT rowandurrant combininggenomicsandepidemiologytoinvestigateazoonoticoutbreakofrabiesinromblonprovincephilippines AT annaformstone combininggenomicsandepidemiologytoinvestigateazoonoticoutbreakofrabiesinromblonprovincephilippines AT darialmanalo combininggenomicsandepidemiologytoinvestigateazoonoticoutbreakofrabiesinromblonprovincephilippines AT duanermanzanilla combininggenomicsandepidemiologytoinvestigateazoonoticoutbreakofrabiesinromblonprovincephilippines AT mikolajkundergorski combininggenomicsandepidemiologytoinvestigateazoonoticoutbreakofrabiesinromblonprovincephilippines AT leilanienacion combininggenomicsandepidemiologytoinvestigateazoonoticoutbreakofrabiesinromblonprovincephilippines AT hannaniahaloyon combininggenomicsandepidemiologytoinvestigateazoonoticoutbreakofrabiesinromblonprovincephilippines AT judekarlobolivar combininggenomicsandepidemiologytoinvestigateazoonoticoutbreakofrabiesinromblonprovincephilippines AT jeromirbondoc combininggenomicsandepidemiologytoinvestigateazoonoticoutbreakofrabiesinromblonprovincephilippines AT christinacobbold combininggenomicsandepidemiologytoinvestigateazoonoticoutbreakofrabiesinromblonprovincephilippines AT efraimpanganiban combininggenomicsandepidemiologytoinvestigateazoonoticoutbreakofrabiesinromblonprovincephilippines AT shynieveemtelmo combininggenomicsandepidemiologytoinvestigateazoonoticoutbreakofrabiesinromblonprovincephilippines AT jobinmaestro combininggenomicsandepidemiologytoinvestigateazoonoticoutbreakofrabiesinromblonprovincephilippines AT maryelizabethgmiranda combininggenomicsandepidemiologytoinvestigateazoonoticoutbreakofrabiesinromblonprovincephilippines AT nairuichng combininggenomicsandepidemiologytoinvestigateazoonoticoutbreakofrabiesinromblonprovincephilippines AT kirstynbrunker combininggenomicsandepidemiologytoinvestigateazoonoticoutbreakofrabiesinromblonprovincephilippines AT katiehampson combininggenomicsandepidemiologytoinvestigateazoonoticoutbreakofrabiesinromblonprovincephilippines |