Divergent Mechanisms of H2AZ.1 and H2AZ.2 in PRC1-Mediated H2A Ubiquitination

Divergent Mechanisms of H2AZ.1 and H2AZ.2 in PRC1-Mediated H2A Ubiquitination

The histone H2A variant H2AZ plays pivotal roles in shaping chromatin architecture and regulating gene expression. We recently identified H2AZ.2 in histone H2A lysine 119 ubiquitination (H2AK119ub)-enriched nucleosomes, but it is not known whether its highly related isoform H2AZ.1 also regulates thi...

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Bibliographic Details
Main Authors: Xiangyu Shen, Chunxu Chen, Amanda E. Jones, Xiaokun Jian, Gengsheng Cao, Hengbin Wang
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
histone variant
H2AZ.1
H2AZ.2
PRC1
H2AK119ub
Online Access:https://www.mdpi.com/2073-4409/14/15/1133
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