GC-MS analysis of cholesterol lowering dietary supplements
Controlling cholesterol levels and reducing the risk of cardiovascular disease requires the development of effective therapeutic strategies. In recent decades, dietary supplements (DSs) have gained attention as potential additions to conventional cholesterol management therapies, but their efficac...
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| Format: | Article |
| Language: | English |
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University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical Association
2024-12-01
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| Series: | Makedonsko Farmacevtski Bilten |
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| Online Access: | https://bulletin.mfd.org.mk/volumes/Volume%2069_1/69_1_004.pdf |
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| author | Velislava Todorova Diana Karcheva-Bahchevanska Stanislava Ivanova |
| author_facet | Velislava Todorova Diana Karcheva-Bahchevanska Stanislava Ivanova |
| author_sort | Velislava Todorova |
| collection | DOAJ |
| description | Controlling cholesterol levels and reducing the risk of cardiovascular disease requires the development of effective therapeutic
strategies. In recent decades, dietary supplements (DSs) have gained attention as potential additions to conventional cholesterol
management therapies, but their efficacy and safety are questionable. Accurate methods are required to evaluate the efficacy and safety of
DSs. In the current study gas chromatography mass spectrometry was performed to analyze ten cholesterol-reducing DSs. The results
showed that monacolin K/lovastatin was present in four samples. Moreover, using effective doses generally has minimal risks and lower
incidence of adverse reactions and drug interactions. However, it must be taken into account the potential interaction of statins to induce
myopathy and rhabdomyolizis. In order to prevent adverse effects, it is necessary to thoroughly evaluate and be careful when using DSs
containing monacolin K. |
| format | Article |
| id | doaj-art-ecdbd088dc544499aca863b08ca4beaf |
| institution | Kabale University |
| issn | 1857-8969 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical Association |
| record_format | Article |
| series | Makedonsko Farmacevtski Bilten |
| spelling | doaj-art-ecdbd088dc544499aca863b08ca4beaf2025-01-11T12:09:14ZengUniversity Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical AssociationMakedonsko Farmacevtski Bilten1857-89692024-12-01691434910.33320/maced.pharm.bull.2023.69.01.004GC-MS analysis of cholesterol lowering dietary supplementsVelislava Todorova0Diana Karcheva-Bahchevanska1Stanislava Ivanova2Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Plovdiv, 4002 Plovdiv, BulgariaDepartment of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Plovdiv, 4002 Plovdiv, BulgariaDepartment of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Plovdiv, 4002 Plovdiv, BulgariaControlling cholesterol levels and reducing the risk of cardiovascular disease requires the development of effective therapeutic strategies. In recent decades, dietary supplements (DSs) have gained attention as potential additions to conventional cholesterol management therapies, but their efficacy and safety are questionable. Accurate methods are required to evaluate the efficacy and safety of DSs. In the current study gas chromatography mass spectrometry was performed to analyze ten cholesterol-reducing DSs. The results showed that monacolin K/lovastatin was present in four samples. Moreover, using effective doses generally has minimal risks and lower incidence of adverse reactions and drug interactions. However, it must be taken into account the potential interaction of statins to induce myopathy and rhabdomyolizis. In order to prevent adverse effects, it is necessary to thoroughly evaluate and be careful when using DSs containing monacolin K.https://bulletin.mfd.org.mk/volumes/Volume%2069_1/69_1_004.pdfcholesterolantihyperlipidemicdietary supplementsgc-ms |
| spellingShingle | Velislava Todorova Diana Karcheva-Bahchevanska Stanislava Ivanova GC-MS analysis of cholesterol lowering dietary supplements Makedonsko Farmacevtski Bilten cholesterol antihyperlipidemic dietary supplements gc-ms |
| title | GC-MS analysis of cholesterol lowering dietary supplements |
| title_full | GC-MS analysis of cholesterol lowering dietary supplements |
| title_fullStr | GC-MS analysis of cholesterol lowering dietary supplements |
| title_full_unstemmed | GC-MS analysis of cholesterol lowering dietary supplements |
| title_short | GC-MS analysis of cholesterol lowering dietary supplements |
| title_sort | gc ms analysis of cholesterol lowering dietary supplements |
| topic | cholesterol antihyperlipidemic dietary supplements gc-ms |
| url | https://bulletin.mfd.org.mk/volumes/Volume%2069_1/69_1_004.pdf |
| work_keys_str_mv | AT velislavatodorova gcmsanalysisofcholesterolloweringdietarysupplements AT dianakarchevabahchevanska gcmsanalysisofcholesterolloweringdietarysupplements AT stanislavaivanova gcmsanalysisofcholesterolloweringdietarysupplements |