Unraveling the effects of FLASH and conventional irradiation on retinal pigment epithelial cells: in vitro and in vivo studies

Unraveling the effects of FLASH and conventional irradiation on retinal pigment epithelial cells: in vitro and in vivo studies

Abstract The retinal pigment epithelium (RPE) is a fundamental monolayer of pigmented cells that supports visual function, situated between the neural retina and choroidal blood vessels. Radiotherapy is a common treatment for ocular tumors such as uveal melanoma; however, the RPE is inevitably expos...

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Bibliographic Details
Main Authors: Beatrice Di Marco, Gabriele Sansevero, Beatrice D’Orsi, Elisa De Santis, Giulia Salamone, Andrea Cavalieri, Luigi Masturzo, Mariagrazia Celentano, Fabio Di Martino, Simone Capaccioli, Daniele Panetta, Fabiola Paiar, Alessandra Gonnelli, Giovanni Gadducci, Mario Costa, Enrica Strettoi
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
FLASH radiotherapy
Retinal pigment epithelium (RPE)
Uveal melanoma
Radiation-induced toxicity
Ocular tumors
Linear accelerator (LINAC)
Online Access:https://doi.org/10.1038/s41598-025-06101-x
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