Monomeric C‐reactive protein induces the cellular pathology of Alzheimer's disease

Monomeric C‐reactive protein induces the cellular pathology of Alzheimer's disease

Abstract Introduction Human study shows that elevated C‐reactive protein (CRP) in blood impacts apolipoprotein E (APOE) ε4, but not APOE ε3 or APOE ε2, genotype to increase the risk of Alzheimer's disease (AD). However, whether CRP is directly involved in cellular AD pathogenesis and in which t...

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Bibliographic Details
Main Authors: Qini Gan, Alfred Wong, Zhengrong Zhang, Hana Na, Hua Tian, Qiushan Tao, Ibraheem M. Rajab, Lawrence A. Potempa, Wei Qiao Qiu
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
Alzheimer's disease
apolipoprotein E (APOE)
astrocyte
microglia
monomeric C‐reactive (mCRP)
synapse
Online Access:https://doi.org/10.1002/trc2.12319
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