Collagen protein-chitosan nerve conduits with neuroepithelial stem cells promote peripheral nerve regeneration
Abstract The peripheral nervous system consists of ganglia, nerve trunks, plexuses, and nerve endings, that transmit afferent and efferent information. Regeneration after a peripheral nerve damage is sluggish and imperfect. Peripheral nerve injury frequently causes partial or complete loss of motor...
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| Language: | English |
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Nature Portfolio
2024-09-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-71435-x |
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| author | Chenping Yun Wei Li Yongjie Qiao Hecun Xiao Baoming Qu Tao Xu Tao Li |
| author_facet | Chenping Yun Wei Li Yongjie Qiao Hecun Xiao Baoming Qu Tao Xu Tao Li |
| author_sort | Chenping Yun |
| collection | DOAJ |
| description | Abstract The peripheral nervous system consists of ganglia, nerve trunks, plexuses, and nerve endings, that transmit afferent and efferent information. Regeneration after a peripheral nerve damage is sluggish and imperfect. Peripheral nerve injury frequently causes partial or complete loss of motor and sensory function, physical impairment, and neuropathic pain, all of which have a negative impact on patients’ quality of life. Because the mechanism of peripheral nerve injury and healing is still unclear, the therapeutic efficacy is limited. As peripheral nerve injury research has processed, an increasing number of studies have revealed that biological scaffolds work in tandem with progenitor cells to repair peripheral nerve injury. Here, we fabricated collagen chitosan nerve conduit bioscaffolds together with collagen and then filled neuroepithelial stem cells (NESCs). Scanning electron microscopy showed that the NESCs grew well on the scaffold surface. Compared to the control group, the NESCs group contained more cells with bigger diameters and myelinated structures around the axons. Our findings indicated that a combination of chitosan-collagen bioscaffold and neural stem cell transplantation can facilitate the functional restoration of peripheral nerve tissue, with promising future applications and research implications. |
| format | Article |
| id | doaj-art-ecd51d4d610a4bd1a9a402de6a4a3376 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-ecd51d4d610a4bd1a9a402de6a4a33762024-11-24T12:21:38ZengNature PortfolioScientific Reports2045-23222024-09-011411910.1038/s41598-024-71435-xCollagen protein-chitosan nerve conduits with neuroepithelial stem cells promote peripheral nerve regenerationChenping Yun0Wei Li1Yongjie Qiao2Hecun Xiao3Baoming Qu4Tao Xu5Tao Li6Shandong First Medical University & Shandong Academy of Medical SciencesDepartment of Anesthesia, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityDepartment of Pharmacy, The People’s Hospital of JimoDepartment of Nephrology, Second Hospital of Shandong UniversityDepartment of Basic Medicine, Qilu Institute of TechnologyDepartment of Traditional Chinese Medicine, Qingdao Women and Children’s Hospital, Qingdao UniversityShandong First Medical University & Shandong Academy of Medical SciencesAbstract The peripheral nervous system consists of ganglia, nerve trunks, plexuses, and nerve endings, that transmit afferent and efferent information. Regeneration after a peripheral nerve damage is sluggish and imperfect. Peripheral nerve injury frequently causes partial or complete loss of motor and sensory function, physical impairment, and neuropathic pain, all of which have a negative impact on patients’ quality of life. Because the mechanism of peripheral nerve injury and healing is still unclear, the therapeutic efficacy is limited. As peripheral nerve injury research has processed, an increasing number of studies have revealed that biological scaffolds work in tandem with progenitor cells to repair peripheral nerve injury. Here, we fabricated collagen chitosan nerve conduit bioscaffolds together with collagen and then filled neuroepithelial stem cells (NESCs). Scanning electron microscopy showed that the NESCs grew well on the scaffold surface. Compared to the control group, the NESCs group contained more cells with bigger diameters and myelinated structures around the axons. Our findings indicated that a combination of chitosan-collagen bioscaffold and neural stem cell transplantation can facilitate the functional restoration of peripheral nerve tissue, with promising future applications and research implications.https://doi.org/10.1038/s41598-024-71435-xChitosanBiological scaffoldsPeripheral nerve regenerationImmune microenvironment |
| spellingShingle | Chenping Yun Wei Li Yongjie Qiao Hecun Xiao Baoming Qu Tao Xu Tao Li Collagen protein-chitosan nerve conduits with neuroepithelial stem cells promote peripheral nerve regeneration Scientific Reports Chitosan Biological scaffolds Peripheral nerve regeneration Immune microenvironment |
| title | Collagen protein-chitosan nerve conduits with neuroepithelial stem cells promote peripheral nerve regeneration |
| title_full | Collagen protein-chitosan nerve conduits with neuroepithelial stem cells promote peripheral nerve regeneration |
| title_fullStr | Collagen protein-chitosan nerve conduits with neuroepithelial stem cells promote peripheral nerve regeneration |
| title_full_unstemmed | Collagen protein-chitosan nerve conduits with neuroepithelial stem cells promote peripheral nerve regeneration |
| title_short | Collagen protein-chitosan nerve conduits with neuroepithelial stem cells promote peripheral nerve regeneration |
| title_sort | collagen protein chitosan nerve conduits with neuroepithelial stem cells promote peripheral nerve regeneration |
| topic | Chitosan Biological scaffolds Peripheral nerve regeneration Immune microenvironment |
| url | https://doi.org/10.1038/s41598-024-71435-x |
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