Early heparin therapy reduces mortality risk in hyperthermic sepsis patients: A retrospective analysis of the MIMIC-Ⅳ database
Objective To investigate the association between body temperature and coagulation function in septic patients, and to evaluate the effect of early heparin therapy on the prognosis of septic patients across varying temperature states. Methods Data were extracted using structured query language(SQL) f...
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Lanzhou University Press
2024-12-01
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| Series: | 生物医学转化 |
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| Online Access: | http://swyxzh.ijournals.cn/swyxzh/article/html/20240405 |
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| author | Xu Haoran Li Yiming Peng Zhiyong |
| author_facet | Xu Haoran Li Yiming Peng Zhiyong |
| author_sort | Xu Haoran |
| collection | DOAJ |
| description | Objective To investigate the association between body temperature and coagulation function in septic patients, and to evaluate the effect of early heparin therapy on the prognosis of septic patients across varying temperature states. Methods Data were extracted using structured query language(SQL) from the MIMIC-Ⅳ database, and clinical characteristics of patients were analyzed with R(4.3.2). Differences in coagulation function across various temperature states and the effect of early heparin therapy on prognosis were examined. Results (1) A non-linear relationship was identified between body temperature and mortality in septic patients; (2) Patients in the hypothermic cohort(≤ 37.0℃) demonstrated prolonged prothrombin time(PT) and partial thromboplastin time (PTT); (3) Early heparin therapy increased mortality risk in the hypothermic cohort(≤ 37.0℃) but decreased mortality risk in the hyperthermic cohort(＞ 38.5℃). Conclusion A significant association exists between body temperature and coagulation function in septic patients. An optimal body temperature range(37.0~38.5°C), along with shorter PT and PTT, may be associated with better prognosis. Early heparin therapy can reduce the mortality risk in hyperthermic patients (＞38.5°C). |
| format | Article |
| id | doaj-art-ecd4f3ee2bbe4b6d9ee7c6f1c4b846bd |
| institution | Kabale University |
| issn | 2096-8965 |
| language | zho |
| publishDate | 2024-12-01 |
| publisher | Lanzhou University Press |
| record_format | Article |
| series | 生物医学转化 |
| spelling | doaj-art-ecd4f3ee2bbe4b6d9ee7c6f1c4b846bd2025-01-13T07:44:30ZzhoLanzhou University Press生物医学转化2096-89652024-12-0154374410.12287/j.issn.2096-8965.20240405Early heparin therapy reduces mortality risk in hyperthermic sepsis patients: A retrospective analysis of the MIMIC-Ⅳ databaseXu Haoran0Li Yiming1Peng Zhiyong2Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University , National Clinical Key Specialtyin Critical Care Medicine , Clinical Research Center of Hubei Critical Care Medicine, Wuhan 430071 , Hubei, ChinaDepartment of Critical Care Medicine, Zhongnan Hospital of Wuhan University , National Clinical Key Specialtyin Critical Care Medicine , Clinical Research Center of Hubei Critical Care Medicine, Wuhan 430071 , Hubei, ChinaDepartment of Critical Care Medicine, Zhongnan Hospital of Wuhan University , National Clinical Key Specialtyin Critical Care Medicine , Clinical Research Center of Hubei Critical Care Medicine, Wuhan 430071 , Hubei, ChinaObjective To investigate the association between body temperature and coagulation function in septic patients, and to evaluate the effect of early heparin therapy on the prognosis of septic patients across varying temperature states. Methods Data were extracted using structured query language(SQL) from the MIMIC-Ⅳ database, and clinical characteristics of patients were analyzed with R(4.3.2). Differences in coagulation function across various temperature states and the effect of early heparin therapy on prognosis were examined. Results (1) A non-linear relationship was identified between body temperature and mortality in septic patients; (2) Patients in the hypothermic cohort(≤ 37.0℃) demonstrated prolonged prothrombin time(PT) and partial thromboplastin time (PTT); (3) Early heparin therapy increased mortality risk in the hypothermic cohort(≤ 37.0℃) but decreased mortality risk in the hyperthermic cohort(＞ 38.5℃). Conclusion A significant association exists between body temperature and coagulation function in septic patients. An optimal body temperature range(37.0~38.5°C), along with shorter PT and PTT, may be associated with better prognosis. Early heparin therapy can reduce the mortality risk in hyperthermic patients (＞38.5°C).http://swyxzh.ijournals.cn/swyxzh/article/html/20240405sepsisbody temperaturemimic databasecoagulation function |
| spellingShingle | Xu Haoran Li Yiming Peng Zhiyong Early heparin therapy reduces mortality risk in hyperthermic sepsis patients: A retrospective analysis of the MIMIC-Ⅳ database 生物医学转化 sepsis body temperature mimic database coagulation function |
| title | Early heparin therapy reduces mortality risk in hyperthermic sepsis patients: A retrospective analysis of the MIMIC-Ⅳ database |
| title_full | Early heparin therapy reduces mortality risk in hyperthermic sepsis patients: A retrospective analysis of the MIMIC-Ⅳ database |
| title_fullStr | Early heparin therapy reduces mortality risk in hyperthermic sepsis patients: A retrospective analysis of the MIMIC-Ⅳ database |
| title_full_unstemmed | Early heparin therapy reduces mortality risk in hyperthermic sepsis patients: A retrospective analysis of the MIMIC-Ⅳ database |
| title_short | Early heparin therapy reduces mortality risk in hyperthermic sepsis patients: A retrospective analysis of the MIMIC-Ⅳ database |
| title_sort | early heparin therapy reduces mortality risk in hyperthermic sepsis patients a retrospective analysis of the mimic iv database |
| topic | sepsis body temperature mimic database coagulation function |
| url | http://swyxzh.ijournals.cn/swyxzh/article/html/20240405 |
| work_keys_str_mv | AT xuhaoran earlyheparintherapyreducesmortalityriskinhyperthermicsepsispatientsaretrospectiveanalysisofthemimicivdatabase AT liyiming earlyheparintherapyreducesmortalityriskinhyperthermicsepsispatientsaretrospectiveanalysisofthemimicivdatabase AT pengzhiyong earlyheparintherapyreducesmortalityriskinhyperthermicsepsispatientsaretrospectiveanalysisofthemimicivdatabase |