Bloodstream infections in pediatric hematology/oncology patients: a single-center study in Wuhan
Bloodstream infections (BSIs) are a critical concern in pediatric onco-hematological patients undergoing chemotherapy or hematopoietic stem cell transplantation (HSCT), leading to a major impact on morbidity, long-term hospitalization, and mortality. We retrospectively analyzed 202 BSIs in 145 patie...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1480952/full |
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| author | Ibrahim Ahmed Saleh Murshed Lizhen Zhao Wenzhi Zhang Yuhong Yin Ying Li Yun Peng Hongbo Chen Xiaoyan Wu |
| author_facet | Ibrahim Ahmed Saleh Murshed Lizhen Zhao Wenzhi Zhang Yuhong Yin Ying Li Yun Peng Hongbo Chen Xiaoyan Wu |
| author_sort | Ibrahim Ahmed Saleh Murshed |
| collection | DOAJ |
| description | Bloodstream infections (BSIs) are a critical concern in pediatric onco-hematological patients undergoing chemotherapy or hematopoietic stem cell transplantation (HSCT), leading to a major impact on morbidity, long-term hospitalization, and mortality. We retrospectively analyzed 202 BSIs in 145 patients, consisting of 128 with hematological malignancies, one with a solid tumor, and 16 with non-malignant hematological diseases. We collected data on patient demographics, clinical characteristics, pathogen distribution, and antimicrobial pathogen susceptibility. Gram-positive infections were the most frequent at (58.4%), followed by gram-negative (41%), and fungal infections (0.5%). Particularly, the majority of these infections occurred during the induction phase of chemotherapy, where 94 (46.5%) BSI episodes were recorded, predominantly in neutropenic patients (88.3%). The consolidation phase experienced lower BSIs (11.8%); among these patients (54.1%) were non-neutropenic. BSIs observed in (23.7%) of patients in the maintenance phase, with a higher proportion (66.6%) being neutropenic. Among the 7 patients who underwent HSCT, BSIs occurred in (4.9%) cases, mainly (70%) due to neutropenia. The most prevalent pathogens were Staphylococcus epidermidis (19.8%), Staphylococcus hominis (16.3%), and Escherichia coli (8.4%). The study highlights the critical need for vigilant monitoring and customized infection management strategies to enhance patient outcomes across chemotherapy phases and HSCT. |
| format | Article |
| id | doaj-art-ecd2fa4a2d9f49668c0bcc10de1aee6e |
| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-ecd2fa4a2d9f49668c0bcc10de1aee6e2024-12-04T06:46:04ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882024-12-011410.3389/fcimb.2024.14809521480952Bloodstream infections in pediatric hematology/oncology patients: a single-center study in WuhanIbrahim Ahmed Saleh MurshedLizhen ZhaoWenzhi ZhangYuhong YinYing LiYun PengHongbo ChenXiaoyan WuBloodstream infections (BSIs) are a critical concern in pediatric onco-hematological patients undergoing chemotherapy or hematopoietic stem cell transplantation (HSCT), leading to a major impact on morbidity, long-term hospitalization, and mortality. We retrospectively analyzed 202 BSIs in 145 patients, consisting of 128 with hematological malignancies, one with a solid tumor, and 16 with non-malignant hematological diseases. We collected data on patient demographics, clinical characteristics, pathogen distribution, and antimicrobial pathogen susceptibility. Gram-positive infections were the most frequent at (58.4%), followed by gram-negative (41%), and fungal infections (0.5%). Particularly, the majority of these infections occurred during the induction phase of chemotherapy, where 94 (46.5%) BSI episodes were recorded, predominantly in neutropenic patients (88.3%). The consolidation phase experienced lower BSIs (11.8%); among these patients (54.1%) were non-neutropenic. BSIs observed in (23.7%) of patients in the maintenance phase, with a higher proportion (66.6%) being neutropenic. Among the 7 patients who underwent HSCT, BSIs occurred in (4.9%) cases, mainly (70%) due to neutropenia. The most prevalent pathogens were Staphylococcus epidermidis (19.8%), Staphylococcus hominis (16.3%), and Escherichia coli (8.4%). The study highlights the critical need for vigilant monitoring and customized infection management strategies to enhance patient outcomes across chemotherapy phases and HSCT.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1480952/fullbacteremiahematologic neoplasmmicroorganismneutropeniapediatric |
| spellingShingle | Ibrahim Ahmed Saleh Murshed Lizhen Zhao Wenzhi Zhang Yuhong Yin Ying Li Yun Peng Hongbo Chen Xiaoyan Wu Bloodstream infections in pediatric hematology/oncology patients: a single-center study in Wuhan Frontiers in Cellular and Infection Microbiology bacteremia hematologic neoplasm microorganism neutropenia pediatric |
| title | Bloodstream infections in pediatric hematology/oncology patients: a single-center study in Wuhan |
| title_full | Bloodstream infections in pediatric hematology/oncology patients: a single-center study in Wuhan |
| title_fullStr | Bloodstream infections in pediatric hematology/oncology patients: a single-center study in Wuhan |
| title_full_unstemmed | Bloodstream infections in pediatric hematology/oncology patients: a single-center study in Wuhan |
| title_short | Bloodstream infections in pediatric hematology/oncology patients: a single-center study in Wuhan |
| title_sort | bloodstream infections in pediatric hematology oncology patients a single center study in wuhan |
| topic | bacteremia hematologic neoplasm microorganism neutropenia pediatric |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1480952/full |
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