Quantitative perturbation-phenotype maps reveal nonlinear responses underlying robustness of PAR-dependent asymmetric cell division.

A key challenge in the development of an organism is to maintain robust phenotypic outcomes in the face of perturbation. Yet, it is often unclear how such robust outcomes are encoded by developmental networks. Here, we use the Caenorhabditis elegans zygote as a model to understand sources of develop...

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Bibliographic Details
Main Authors: Nelio T L Rodrigues, Tom Bland, KangBo Ng, Nisha Hirani, Nathan W Goehring
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-12-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3002437
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