Apelin/APJ system: a novel promising target for anti-oxidative stress in stroke
The apelin/APJ system has garnered increasing attention in recent years. In this review, we comprehensively discuss the physiological and pathological mechanisms of the apelin/APJ system in stroke. The apelin/APJ system is widely expressed in the central nervous system (CNS). However, the distributi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1352927/full |
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| author | Weilin Xu Weilin Xu Jun Yan Zachary D. Travis Cameron Lenahan Liansheng Gao Liansheng Gao Haijian Wu Haijian Wu Jingwei Zheng Jingwei Zheng Jianmin Zhang Jianmin Zhang Anwen Shao Anwen Shao Jun Yu Jun Yu |
| author_facet | Weilin Xu Weilin Xu Jun Yan Zachary D. Travis Cameron Lenahan Liansheng Gao Liansheng Gao Haijian Wu Haijian Wu Jingwei Zheng Jingwei Zheng Jianmin Zhang Jianmin Zhang Anwen Shao Anwen Shao Jun Yu Jun Yu |
| author_sort | Weilin Xu |
| collection | DOAJ |
| description | The apelin/APJ system has garnered increasing attention in recent years. In this review, we comprehensively discuss the physiological and pathological mechanisms of the apelin/APJ system in stroke. The apelin/APJ system is widely expressed in the central nervous system (CNS). However, the distribution of the apelin/APJ system varies across different regions and subcellular organelles of the brain. Additionally, the neuroprotective effects of the apelin/APJ system have been reported to inhibit oxidative and nitrative stresses via various signaling pathways. Despite this, the clinical application of the apelin/APJ system remains distant, as apelin has numerous active forms and signaling pathways. The development of a range of drugs targeting the apelin/APJ system holds promise for treating stroke. |
| format | Article |
| id | doaj-art-ecb0a736d0584213bebfde297de04ca8 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-ecb0a736d0584213bebfde297de04ca82025-01-15T09:44:16ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.13529271352927Apelin/APJ system: a novel promising target for anti-oxidative stress in strokeWeilin Xu0Weilin Xu1Jun Yan2Zachary D. Travis3Cameron Lenahan4Liansheng Gao5Liansheng Gao6Haijian Wu7Haijian Wu8Jingwei Zheng9Jingwei Zheng10Jianmin Zhang11Jianmin Zhang12Anwen Shao13Anwen Shao14Jun Yu15Jun Yu16Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaKey Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, ChinaDepartment of Neurosurgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Medical Science Education, College of Health Sciences, Western University of Health Sciences, Pomona, CA, United StatesBurrell College of Osteopathic Medicine, New Mexico State University, Las Cruces, NM, United StatesDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaKey Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaKey Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaKey Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaKey Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaKey Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaKey Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, ChinaThe apelin/APJ system has garnered increasing attention in recent years. In this review, we comprehensively discuss the physiological and pathological mechanisms of the apelin/APJ system in stroke. The apelin/APJ system is widely expressed in the central nervous system (CNS). However, the distribution of the apelin/APJ system varies across different regions and subcellular organelles of the brain. Additionally, the neuroprotective effects of the apelin/APJ system have been reported to inhibit oxidative and nitrative stresses via various signaling pathways. Despite this, the clinical application of the apelin/APJ system remains distant, as apelin has numerous active forms and signaling pathways. The development of a range of drugs targeting the apelin/APJ system holds promise for treating stroke.https://www.frontiersin.org/articles/10.3389/fphar.2024.1352927/fullapelinAPJstrokeoxidative stressneuroprotection |
| spellingShingle | Weilin Xu Weilin Xu Jun Yan Zachary D. Travis Cameron Lenahan Liansheng Gao Liansheng Gao Haijian Wu Haijian Wu Jingwei Zheng Jingwei Zheng Jianmin Zhang Jianmin Zhang Anwen Shao Anwen Shao Jun Yu Jun Yu Apelin/APJ system: a novel promising target for anti-oxidative stress in stroke Frontiers in Pharmacology apelin APJ stroke oxidative stress neuroprotection |
| title | Apelin/APJ system: a novel promising target for anti-oxidative stress in stroke |
| title_full | Apelin/APJ system: a novel promising target for anti-oxidative stress in stroke |
| title_fullStr | Apelin/APJ system: a novel promising target for anti-oxidative stress in stroke |
| title_full_unstemmed | Apelin/APJ system: a novel promising target for anti-oxidative stress in stroke |
| title_short | Apelin/APJ system: a novel promising target for anti-oxidative stress in stroke |
| title_sort | apelin apj system a novel promising target for anti oxidative stress in stroke |
| topic | apelin APJ stroke oxidative stress neuroprotection |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1352927/full |
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