Epidural analgesia during surgery and its relation to postoperative myocardial infarction: meta-analysis
Introduction: Epidural analgesia has been studied for its potential advantages after surgery in a number of random ized clinical trials, with most finding improvements in pain and secondary endpoints like the incidence of postoper ative complications. Aim: To assess the relationship between use...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Medycyna Praktyczna
2024-03-01
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| Series: | Videosurgery and Other Miniinvasive Techniques |
| Subjects: | |
| Online Access: | https://www.mp.pl/videosurgery/issue/article/17839/ |
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| Summary: | Introduction: Epidural analgesia has been studied for its potential advantages after surgery in a number of random
ized clinical trials, with most finding improvements in pain and secondary endpoints like the incidence of postoper
ative complications.
Aim: To assess the relationship between use of epidural analgesia and adverse cardiac outcomes expressed by myo
cardial infarction (MI).
Material and methods: Fifty-three studies were recruited to quantify the influence of different surgical-related anal
gesic methods on clinical parameters (mortality and adverse events). The results of these trials were analysed using
a random effects model, which was then used to calculate the mean difference (MD) with 95 per cent confidence
intervals (CIs).
Results: Epidural analgesia resulted in preferred cardiac outcomes compared with traditional analgesia. These find
ings were supported by significantly lower MI events for the epidural analgesia group as follows: p = 0.005, p = 0,007,
and p = 0.03 for the total number of included studies, studies with high risk of bias, and studies with low risk of bias,
respectively. Studies with intermediate risk showed a non-significant difference between both groups (p = 0.7).
Conclusions: Epidural analgesia has a significant protective cardiac effect through the reduction of postoperative MI
events among surgery subjects. |
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| ISSN: | 1895-4588 2299-0054 |