Impact of unintentional weight loss on 30-day mortality in intensive care unit sepsis patients: a retrospective cohort study
Abstract This study aimed to investigate the relationship between unintentional weight loss and 30-day mortality in sepsis patients in the intensive care unit (ICU). A retrospective cohort study sepsis patients in the ICU was conducted using data from the Medical Information Mart for Intensive Care...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-12-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-83260-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846101158395904000 |
|---|---|
| author | Weide Lin Bixia Lin Junfan Chen Renwei Li Yaohua Yu Shiqing Huang Shurong Li Jing Lin |
| author_facet | Weide Lin Bixia Lin Junfan Chen Renwei Li Yaohua Yu Shiqing Huang Shurong Li Jing Lin |
| author_sort | Weide Lin |
| collection | DOAJ |
| description | Abstract This study aimed to investigate the relationship between unintentional weight loss and 30-day mortality in sepsis patients in the intensive care unit (ICU). A retrospective cohort study sepsis patients in the ICU was conducted using data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database, involving 1842 sepsis patients in the ICU. We utilized multivariate Cox regression analysis to evaluate the association between unintentional weight loss and the risk of 30-day mortality. In addition, we conducted stratified and interaction analyses to determine the consistency of this association across various demographic and clinical subgroups. Out of the 1842 patients, 19.2% (354) died within 30 days. The fully adjusted multivariate Cox regression model revealed that for every one-unit decrease in body weight, the risk of death increased by 58% (hazard ratio [HR] = 1.58; 95% confidence interval [CI] = 1.20–2.07). Unintentional weight loss was found to be positively correlated with 30-day mortality. Subgroup analysis yielded consistent results across all groups. Unintentional weight loss was positively associated with a greater risk of mortality in critically ill patients with sepsis in the ICU. |
| format | Article |
| id | doaj-art-ec883c69ba16454d9e27f76b5e5f5f8b |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-ec883c69ba16454d9e27f76b5e5f5f8b2024-12-29T12:28:27ZengNature PortfolioScientific Reports2045-23222024-12-0114111010.1038/s41598-024-83260-3Impact of unintentional weight loss on 30-day mortality in intensive care unit sepsis patients: a retrospective cohort studyWeide Lin0Bixia Lin1Junfan Chen2Renwei Li3Yaohua Yu4Shiqing Huang5Shurong Li6Jing Lin7Department of Anesthesiology, The First Hospital of Putian CityDepartment of Ultrasonography, The First Hospital of Putian CityDepartment of Anesthesiology, The First Hospital of Putian CityDepartment of Anesthesiology, The First Hospital of Putian CityDepartment of Anesthesiology, The First Hospital of Putian CityDepartment of Anesthesiology, The First Hospital of Putian CityDepartment of Anesthesiology, The First Hospital of Putian CityDepartment of Anesthesiology, The First Hospital of Putian CityAbstract This study aimed to investigate the relationship between unintentional weight loss and 30-day mortality in sepsis patients in the intensive care unit (ICU). A retrospective cohort study sepsis patients in the ICU was conducted using data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database, involving 1842 sepsis patients in the ICU. We utilized multivariate Cox regression analysis to evaluate the association between unintentional weight loss and the risk of 30-day mortality. In addition, we conducted stratified and interaction analyses to determine the consistency of this association across various demographic and clinical subgroups. Out of the 1842 patients, 19.2% (354) died within 30 days. The fully adjusted multivariate Cox regression model revealed that for every one-unit decrease in body weight, the risk of death increased by 58% (hazard ratio [HR] = 1.58; 95% confidence interval [CI] = 1.20–2.07). Unintentional weight loss was found to be positively correlated with 30-day mortality. Subgroup analysis yielded consistent results across all groups. Unintentional weight loss was positively associated with a greater risk of mortality in critically ill patients with sepsis in the ICU.https://doi.org/10.1038/s41598-024-83260-3Unintentional weight lossSepsis30-day mortalityRetrospective cohort study |
| spellingShingle | Weide Lin Bixia Lin Junfan Chen Renwei Li Yaohua Yu Shiqing Huang Shurong Li Jing Lin Impact of unintentional weight loss on 30-day mortality in intensive care unit sepsis patients: a retrospective cohort study Scientific Reports Unintentional weight loss Sepsis 30-day mortality Retrospective cohort study |
| title | Impact of unintentional weight loss on 30-day mortality in intensive care unit sepsis patients: a retrospective cohort study |
| title_full | Impact of unintentional weight loss on 30-day mortality in intensive care unit sepsis patients: a retrospective cohort study |
| title_fullStr | Impact of unintentional weight loss on 30-day mortality in intensive care unit sepsis patients: a retrospective cohort study |
| title_full_unstemmed | Impact of unintentional weight loss on 30-day mortality in intensive care unit sepsis patients: a retrospective cohort study |
| title_short | Impact of unintentional weight loss on 30-day mortality in intensive care unit sepsis patients: a retrospective cohort study |
| title_sort | impact of unintentional weight loss on 30 day mortality in intensive care unit sepsis patients a retrospective cohort study |
| topic | Unintentional weight loss Sepsis 30-day mortality Retrospective cohort study |
| url | https://doi.org/10.1038/s41598-024-83260-3 |
| work_keys_str_mv | AT weidelin impactofunintentionalweightlosson30daymortalityinintensivecareunitsepsispatientsaretrospectivecohortstudy AT bixialin impactofunintentionalweightlosson30daymortalityinintensivecareunitsepsispatientsaretrospectivecohortstudy AT junfanchen impactofunintentionalweightlosson30daymortalityinintensivecareunitsepsispatientsaretrospectivecohortstudy AT renweili impactofunintentionalweightlosson30daymortalityinintensivecareunitsepsispatientsaretrospectivecohortstudy AT yaohuayu impactofunintentionalweightlosson30daymortalityinintensivecareunitsepsispatientsaretrospectivecohortstudy AT shiqinghuang impactofunintentionalweightlosson30daymortalityinintensivecareunitsepsispatientsaretrospectivecohortstudy AT shurongli impactofunintentionalweightlosson30daymortalityinintensivecareunitsepsispatientsaretrospectivecohortstudy AT jinglin impactofunintentionalweightlosson30daymortalityinintensivecareunitsepsispatientsaretrospectivecohortstudy |