Clinical Trial of Autologous Dendritic Cell Administration Effect on Water Molecule Diffusion and Anti-Inflammatory Biomarkers in Diabetic Kidney Disease
Diabetic kidney disease (DKD) significantly increases mortality, with patients facing a fourfold risk of death within ten years. Chronic inflammation, marked by transforming growth factor-β (TGF-β) and intracellular adhesion molecule-1 (ICAM-1) activity, contributes to kidney damage and fibrosis. Th...
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2024-12-01
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| author | Paulus Stefanus Dimu Aziza Ghanie Icksan Farhat Jonny Bhimo Aji Hernowo Terawan Agus Putranto |
| author_facet | Paulus Stefanus Dimu Aziza Ghanie Icksan Farhat Jonny Bhimo Aji Hernowo Terawan Agus Putranto |
| author_sort | Paulus Stefanus Dimu |
| collection | DOAJ |
| description | Diabetic kidney disease (DKD) significantly increases mortality, with patients facing a fourfold risk of death within ten years. Chronic inflammation, marked by transforming growth factor-β (TGF-β) and intracellular adhesion molecule-1 (ICAM-1) activity, contributes to kidney damage and fibrosis. This study investigates the effect of autologous dendritic cells on inflammation and kidney function, focusing on apparent diffusion coefficient (ADC), TGF-β, and ICAM-1 levels. This quasi-experimental clinical trial involved 22 DKD patients at Gatot Soebroto Army Hospital. Patients received autologous dendritic cell injections. Baseline and post-intervention magnetic resonance imaging (MRI) scans measured ADC values, and ICAM-1 and TGF-β levels were analyzed. Post intervention, the median ADC decreased from 1.75 mm<sup>2</sup>/s to 1.64 mm<sup>2</sup>/s (<i>p</i> = 0.223). ICAM-1 levels increased significantly in females (<i>p</i> = 0.04) but not in males (<i>p</i> = 0.35). No significant changes were found in TGF-β levels (<i>p</i> = 0.506). ADC changes were statistically insignificant and did not correlate with CKD severity. ICAM-1 increases in females correlated with improved creatinine levels, suggesting kidney function improvement. Autologous dendritic cell therapy revealed potential gender-specific immune responses but showed limited overall biomarker improvements. Further studies are required to validate its therapeutic value. |
| format | Article |
| id | doaj-art-ec83369207a14a3d9fce15ff269a20b2 |
| institution | Kabale University |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2024-12-01 |
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| series | Current Issues in Molecular Biology |
| spelling | doaj-art-ec83369207a14a3d9fce15ff269a20b22024-12-27T14:18:13ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452024-12-014612137671377910.3390/cimb46120822Clinical Trial of Autologous Dendritic Cell Administration Effect on Water Molecule Diffusion and Anti-Inflammatory Biomarkers in Diabetic Kidney DiseasePaulus Stefanus Dimu0Aziza Ghanie Icksan1Farhat2Jonny3Bhimo Aji Hernowo4Terawan Agus Putranto5Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Medan 20118, IndonesiaFaculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Medan 20118, IndonesiaFaculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Medan 20118, IndonesiaFaculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Medan 20118, IndonesiaFaculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Medan 20118, IndonesiaFaculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Medan 20118, IndonesiaDiabetic kidney disease (DKD) significantly increases mortality, with patients facing a fourfold risk of death within ten years. Chronic inflammation, marked by transforming growth factor-β (TGF-β) and intracellular adhesion molecule-1 (ICAM-1) activity, contributes to kidney damage and fibrosis. This study investigates the effect of autologous dendritic cells on inflammation and kidney function, focusing on apparent diffusion coefficient (ADC), TGF-β, and ICAM-1 levels. This quasi-experimental clinical trial involved 22 DKD patients at Gatot Soebroto Army Hospital. Patients received autologous dendritic cell injections. Baseline and post-intervention magnetic resonance imaging (MRI) scans measured ADC values, and ICAM-1 and TGF-β levels were analyzed. Post intervention, the median ADC decreased from 1.75 mm<sup>2</sup>/s to 1.64 mm<sup>2</sup>/s (<i>p</i> = 0.223). ICAM-1 levels increased significantly in females (<i>p</i> = 0.04) but not in males (<i>p</i> = 0.35). No significant changes were found in TGF-β levels (<i>p</i> = 0.506). ADC changes were statistically insignificant and did not correlate with CKD severity. ICAM-1 increases in females correlated with improved creatinine levels, suggesting kidney function improvement. Autologous dendritic cell therapy revealed potential gender-specific immune responses but showed limited overall biomarker improvements. Further studies are required to validate its therapeutic value.https://www.mdpi.com/1467-3045/46/12/822diabetic kidney diseasediffusion-weighted MRIapparent diffusion coefficientintracellular adhesion molecule-1transforming growth factor-βautologous dendritic cells |
| spellingShingle | Paulus Stefanus Dimu Aziza Ghanie Icksan Farhat Jonny Bhimo Aji Hernowo Terawan Agus Putranto Clinical Trial of Autologous Dendritic Cell Administration Effect on Water Molecule Diffusion and Anti-Inflammatory Biomarkers in Diabetic Kidney Disease Current Issues in Molecular Biology diabetic kidney disease diffusion-weighted MRI apparent diffusion coefficient intracellular adhesion molecule-1 transforming growth factor-β autologous dendritic cells |
| title | Clinical Trial of Autologous Dendritic Cell Administration Effect on Water Molecule Diffusion and Anti-Inflammatory Biomarkers in Diabetic Kidney Disease |
| title_full | Clinical Trial of Autologous Dendritic Cell Administration Effect on Water Molecule Diffusion and Anti-Inflammatory Biomarkers in Diabetic Kidney Disease |
| title_fullStr | Clinical Trial of Autologous Dendritic Cell Administration Effect on Water Molecule Diffusion and Anti-Inflammatory Biomarkers in Diabetic Kidney Disease |
| title_full_unstemmed | Clinical Trial of Autologous Dendritic Cell Administration Effect on Water Molecule Diffusion and Anti-Inflammatory Biomarkers in Diabetic Kidney Disease |
| title_short | Clinical Trial of Autologous Dendritic Cell Administration Effect on Water Molecule Diffusion and Anti-Inflammatory Biomarkers in Diabetic Kidney Disease |
| title_sort | clinical trial of autologous dendritic cell administration effect on water molecule diffusion and anti inflammatory biomarkers in diabetic kidney disease |
| topic | diabetic kidney disease diffusion-weighted MRI apparent diffusion coefficient intracellular adhesion molecule-1 transforming growth factor-β autologous dendritic cells |
| url | https://www.mdpi.com/1467-3045/46/12/822 |
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