Research on detection methods of related substances and degradation products of the antitumor drug selpercatinib

Research on detection methods of related substances and degradation products of the antitumor drug selpercatinib

BackgroundSelpercatinib, a selective RET kinase inhibitor, is approved for treating various cancers with RET gene mutations such as RET-rearranged thyroid cancer and non-small cell lung cancer. The presence of process-related and degradation impurities in its active pharmaceutical ingredient (API) c...

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Bibliographic Details
Main Authors: Jingjing Xiang, Liangliang Cai, Qin Wang, Yonghong Zhu, Yong Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Chemistry
Subjects:
selpercatinib
related substances
degradation products
method development
method validation
liquid chromatography
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2024.1534132/full
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