Efferent compared to afferent neural substrates of the vergence eye movement system evoked via fMRI
IntroductionThe vergence neural system was stimulated to dissect the afferent and efferent components of symmetrical vergence eye movement step responses. The hypothesis tested was whether the afferent regions of interest would differ from the efferent regions to serve as comparative data for future...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1497326/full |
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| author | Ayushi Sangoi Farzin Hajebrahimi Suril Gohel Mitchell Scheiman Tara L. Alvarez |
| author_facet | Ayushi Sangoi Farzin Hajebrahimi Suril Gohel Mitchell Scheiman Tara L. Alvarez |
| author_sort | Ayushi Sangoi |
| collection | DOAJ |
| description | IntroductionThe vergence neural system was stimulated to dissect the afferent and efferent components of symmetrical vergence eye movement step responses. The hypothesis tested was whether the afferent regions of interest would differ from the efferent regions to serve as comparative data for future clinical patient population studies.MethodsThirty binocularly normal participants participated in an oculomotor symmetrical vergence step block task within a functional MRI experiment compared to a similar sensory task where the participants did not elicit vergence eye movements.ResultsFor the oculomotor vergence task, functional activation was observed within the parietal eye field, supplemental eye field, frontal eye field, and cerebellar vermis, and activation in these regions was significantly diminished during the sensory task. Differences between the afferent sensory and efferent oculomotor experiments were also observed within the visual cortex.DiscussionDifferences between the vergence oculomotor and sensory tasks provide a protocol to delineate the afferent and efferent portion of the vergence neural circuit. Implications with clinical populations and future therapeutic intervention studies are discussed. |
| format | Article |
| id | doaj-art-ec72672a85f848058d36984cf836734a |
| institution | Kabale University |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj-art-ec72672a85f848058d36984cf836734a2025-01-08T06:11:41ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-01-011810.3389/fnins.2024.14973261497326Efferent compared to afferent neural substrates of the vergence eye movement system evoked via fMRIAyushi Sangoi0Farzin Hajebrahimi1Suril Gohel2Mitchell Scheiman3Tara L. Alvarez4Vision and Neural Engineering Laboratory, Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, United StatesVision and Neural Engineering Laboratory, Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, United StatesDepartment of Health Informatics, Rutgers University School of Health Professions, Newark, NJ, United StatesPennsylvania College of Optometry at Drexel University, Philadelphia, PA, United StatesVision and Neural Engineering Laboratory, Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, United StatesIntroductionThe vergence neural system was stimulated to dissect the afferent and efferent components of symmetrical vergence eye movement step responses. The hypothesis tested was whether the afferent regions of interest would differ from the efferent regions to serve as comparative data for future clinical patient population studies.MethodsThirty binocularly normal participants participated in an oculomotor symmetrical vergence step block task within a functional MRI experiment compared to a similar sensory task where the participants did not elicit vergence eye movements.ResultsFor the oculomotor vergence task, functional activation was observed within the parietal eye field, supplemental eye field, frontal eye field, and cerebellar vermis, and activation in these regions was significantly diminished during the sensory task. Differences between the afferent sensory and efferent oculomotor experiments were also observed within the visual cortex.DiscussionDifferences between the vergence oculomotor and sensory tasks provide a protocol to delineate the afferent and efferent portion of the vergence neural circuit. Implications with clinical populations and future therapeutic intervention studies are discussed.https://www.frontiersin.org/articles/10.3389/fnins.2024.1497326/fullvergencefMRIsensorimotorafferentefferent |
| spellingShingle | Ayushi Sangoi Farzin Hajebrahimi Suril Gohel Mitchell Scheiman Tara L. Alvarez Efferent compared to afferent neural substrates of the vergence eye movement system evoked via fMRI Frontiers in Neuroscience vergence fMRI sensorimotor afferent efferent |
| title | Efferent compared to afferent neural substrates of the vergence eye movement system evoked via fMRI |
| title_full | Efferent compared to afferent neural substrates of the vergence eye movement system evoked via fMRI |
| title_fullStr | Efferent compared to afferent neural substrates of the vergence eye movement system evoked via fMRI |
| title_full_unstemmed | Efferent compared to afferent neural substrates of the vergence eye movement system evoked via fMRI |
| title_short | Efferent compared to afferent neural substrates of the vergence eye movement system evoked via fMRI |
| title_sort | efferent compared to afferent neural substrates of the vergence eye movement system evoked via fmri |
| topic | vergence fMRI sensorimotor afferent efferent |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1497326/full |
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