In vitro, in vivo, and in silico evidence for the use of plant pigments betalains as potential nutraceuticals against Alzheimer's disease
Abstract Anti‐amyloidogenic properties of plant pigments betalains as potential nutraceuticals against Alzheimer's disease have been screened using 24 pure molecules. Twenty‐two betalains reduced amyloid aggregation in vitro, eight of them up to 100%, with IC50 values in the micromolar range. A...
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| Format: | Article |
| Language: | English |
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Wiley
2024-09-01
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| Series: | Food Frontiers |
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| Online Access: | https://doi.org/10.1002/fft2.453 |
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| author | Pedro Martínez‐Rodríguez Paula Henarejos‐Escudero Samanta Hernández‐García Álvaro Sánchez‐Ferrer Fernando Gandía‐Herrero |
| author_facet | Pedro Martínez‐Rodríguez Paula Henarejos‐Escudero Samanta Hernández‐García Álvaro Sánchez‐Ferrer Fernando Gandía‐Herrero |
| author_sort | Pedro Martínez‐Rodríguez |
| collection | DOAJ |
| description | Abstract Anti‐amyloidogenic properties of plant pigments betalains as potential nutraceuticals against Alzheimer's disease have been screened using 24 pure molecules. Twenty‐two betalains reduced amyloid aggregation in vitro, eight of them up to 100%, with IC50 values in the micromolar range. Atomic force and transmission electron microscopy images showed the typical fibrils associated with Alzheimer's disease and how betalains avoid its formation. Neuroprotection after ingestion was supported by in vivo experiments with Caenorhabditis elegans. Indoline‐betacyanin was the most effective molecule by significantly improving the chemotactic behavior of the CL2355 strain, a model of Alzheimer's disease. Furthermore, in‐depth molecular docking analyses revealed that the pigments interact with the N‐terminal region of the amyloid peptide. This work is the most comprehensive study in the field and provides in vitro, in vivo, and in silico evidence for the use of betalains as nutraceuticals of relevance in the prevention of Alzheimer's disease. |
| format | Article |
| id | doaj-art-ec5eef7f545a4ce68357fc80d97c7bf2 |
| institution | Kabale University |
| issn | 2643-8429 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Frontiers |
| spelling | doaj-art-ec5eef7f545a4ce68357fc80d97c7bf22024-11-17T09:43:58ZengWileyFood Frontiers2643-84292024-09-01552137215410.1002/fft2.453In vitro, in vivo, and in silico evidence for the use of plant pigments betalains as potential nutraceuticals against Alzheimer's diseasePedro Martínez‐Rodríguez0Paula Henarejos‐Escudero1Samanta Hernández‐García2Álvaro Sánchez‐Ferrer3Fernando Gandía‐Herrero4Department of Biochemistry and Molecular Biology A, Faculty of Biology, Regional Campus of International Excellence, Campus Mare Nostrum University of Murcia Murcia SpainDepartment of Biochemistry and Molecular Biology A, Faculty of Biology, Regional Campus of International Excellence, Campus Mare Nostrum University of Murcia Murcia SpainDepartment of Biochemistry and Molecular Biology A, Faculty of Biology, Regional Campus of International Excellence, Campus Mare Nostrum University of Murcia Murcia SpainDepartment of Biochemistry and Molecular Biology A, Faculty of Biology, Regional Campus of International Excellence, Campus Mare Nostrum University of Murcia Murcia SpainDepartment of Biochemistry and Molecular Biology A, Faculty of Biology, Regional Campus of International Excellence, Campus Mare Nostrum University of Murcia Murcia SpainAbstract Anti‐amyloidogenic properties of plant pigments betalains as potential nutraceuticals against Alzheimer's disease have been screened using 24 pure molecules. Twenty‐two betalains reduced amyloid aggregation in vitro, eight of them up to 100%, with IC50 values in the micromolar range. Atomic force and transmission electron microscopy images showed the typical fibrils associated with Alzheimer's disease and how betalains avoid its formation. Neuroprotection after ingestion was supported by in vivo experiments with Caenorhabditis elegans. Indoline‐betacyanin was the most effective molecule by significantly improving the chemotactic behavior of the CL2355 strain, a model of Alzheimer's disease. Furthermore, in‐depth molecular docking analyses revealed that the pigments interact with the N‐terminal region of the amyloid peptide. This work is the most comprehensive study in the field and provides in vitro, in vivo, and in silico evidence for the use of betalains as nutraceuticals of relevance in the prevention of Alzheimer's disease.https://doi.org/10.1002/fft2.453Alzheimer's disease (AD)betalainsbioactive pigmentsCaenorhabditis elegansneuroprotectionnutraceuticals |
| spellingShingle | Pedro Martínez‐Rodríguez Paula Henarejos‐Escudero Samanta Hernández‐García Álvaro Sánchez‐Ferrer Fernando Gandía‐Herrero In vitro, in vivo, and in silico evidence for the use of plant pigments betalains as potential nutraceuticals against Alzheimer's disease Food Frontiers Alzheimer's disease (AD) betalains bioactive pigments Caenorhabditis elegans neuroprotection nutraceuticals |
| title | In vitro, in vivo, and in silico evidence for the use of plant pigments betalains as potential nutraceuticals against Alzheimer's disease |
| title_full | In vitro, in vivo, and in silico evidence for the use of plant pigments betalains as potential nutraceuticals against Alzheimer's disease |
| title_fullStr | In vitro, in vivo, and in silico evidence for the use of plant pigments betalains as potential nutraceuticals against Alzheimer's disease |
| title_full_unstemmed | In vitro, in vivo, and in silico evidence for the use of plant pigments betalains as potential nutraceuticals against Alzheimer's disease |
| title_short | In vitro, in vivo, and in silico evidence for the use of plant pigments betalains as potential nutraceuticals against Alzheimer's disease |
| title_sort | in vitro in vivo and in silico evidence for the use of plant pigments betalains as potential nutraceuticals against alzheimer s disease |
| topic | Alzheimer's disease (AD) betalains bioactive pigments Caenorhabditis elegans neuroprotection nutraceuticals |
| url | https://doi.org/10.1002/fft2.453 |
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