Unraveling the causal impact of smoking and its DNA methylation signatures on cardiovascular disease: Mendelian randomization and colocalization analysis

Unraveling the causal impact of smoking and its DNA methylation signatures on cardiovascular disease: Mendelian randomization and colocalization analysis

Abstract Background To explore the mechanisms linking smoking to cardiovascular diseases (CVDs) from an epigenetic perspective. Methods Mendelian Randomization (MR) analysis was performed to assess the causal effects of smoking behavior and DNA methylation levels at smoking-related CpG sites on nine...

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Main Authors: Si Cao, Youjie Zeng, Ke Pang, Minghua Chen, Ren Guo, Nayiyuan Wu, Chao Fang, Huiyin Deng, Xiaoyi Zhang, Xiaohui Xie, Wen Ouyang, Heng Yang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Clinical Epigenetics
Subjects:
Mendelian randomization
Cigarette smoking
DNA methylation
Cardiovascular diseases
Causal inference
Risk factors
Online Access:https://doi.org/10.1186/s13148-024-01808-6
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