Impact of platelet-lymphocyte ratio after robot-assisted partial nephrectomy with renorrhaphy
Abstract Renorrhaphy is often performed after tumor resection during robotic-assisted laparoscopic partial nephrectomy (RAPN). This study aimed to investigate the association between renorrhaphy performance and inflammatory markers. A retrospective cohort study was conducted including patients with...
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Nature Portfolio
2024-12-01
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| Online Access: | https://doi.org/10.1038/s41598-024-82197-x |
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| author | Tomoki Taniguchi Kentaro Muraoka Kohei Nishikawa Yoshinori Ikehata Kiyoshi Setoguchi Suguru Oka Shin Ebara Akira Fujisaki Kazuhide Makiyama Takahiro Inoue Hiroshi Kitamura Kazutaka Saito Shinji Urakami Tatsuaki Yoneda Takuya Koie |
| author_facet | Tomoki Taniguchi Kentaro Muraoka Kohei Nishikawa Yoshinori Ikehata Kiyoshi Setoguchi Suguru Oka Shin Ebara Akira Fujisaki Kazuhide Makiyama Takahiro Inoue Hiroshi Kitamura Kazutaka Saito Shinji Urakami Tatsuaki Yoneda Takuya Koie |
| author_sort | Tomoki Taniguchi |
| collection | DOAJ |
| description | Abstract Renorrhaphy is often performed after tumor resection during robotic-assisted laparoscopic partial nephrectomy (RAPN). This study aimed to investigate the association between renorrhaphy performance and inflammatory markers. A retrospective cohort study was conducted including patients with renal cell carcinoma who underwent RAPN at eight institutions in Japan between April 2016 and November 2023. The primary endpoint was the association between the renorrhaphy performance in RAPN and the postoperative inflammatory markers. The secondary endpoints were perioperative outcomes in patients with and without renorrhaphy. The patients were divided into two groups at the time of RAPN: those who underwent renorrhaphy (renorrhaphy group) and those who did not (omitted group). In total, 934 patients were enrolled in this study. After propensity score matching, the rate of change in C-reactive protein and neutrophil-lymphocyte ratio on postoperative day 28 were not significant difference between the two groups. In contrast, the rate of change in platelet-lymphocyte ratio (PLR) on postoperative day 28 was significantly higher in renorrhaphy group than omitted group. Regarding surgical outcomes, the renorrhaphy group had a significantly longer hospital stay, operative time, and warm ischemia time (P = 0.038, P = 0.022, and P = 0.009, respectively) than the omitted group did. Furthermore, the omitted group had a significantly higher rate of Trifecta achievement than the renorrhaphy group did. This study demonstrated that renorrhaphy performance in RAPN was significantly associated with the higher value of postoperative PLR. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-ec44c28ee3e74f3dafcad5aa5b1201b42024-12-29T12:23:13ZengNature PortfolioScientific Reports2045-23222024-12-011411710.1038/s41598-024-82197-xImpact of platelet-lymphocyte ratio after robot-assisted partial nephrectomy with renorrhaphyTomoki Taniguchi0Kentaro Muraoka1Kohei Nishikawa2Yoshinori Ikehata3Kiyoshi Setoguchi4Suguru Oka5Shin Ebara6Akira Fujisaki7Kazuhide Makiyama8Takahiro Inoue9Hiroshi Kitamura10Kazutaka Saito11Shinji Urakami12Tatsuaki Yoneda13Takuya Koie14Department of Urology, Graduate School of Medicine, Gifu UniversityDepartment of Urology, Graduate School of Medicine, Yokohama City UniversityDepartment of Urology, Graduate School of Medicine, Mie UniversityDepartment of Urology, Graduate School of Medicine, Toyama UniversityDepartment of Urology, Dokkyo Medical University Saitama Medical CenterDepartment of Urology, Toranomon HospitalDepartment of Urology, Hiroshima City Hiroshima Citizens HospitalDepartment of Urology, Seirei Hamamatsu General HospitalDepartment of Urology, Graduate School of Medicine, Yokohama City UniversityDepartment of Urology, Graduate School of Medicine, Mie UniversityDepartment of Urology, Graduate School of Medicine, Toyama UniversityDepartment of Urology, Dokkyo Medical University Saitama Medical CenterDepartment of Urology, Toranomon HospitalDepartment of Urology, Seirei Hamamatsu General HospitalDepartment of Urology, Graduate School of Medicine, Gifu UniversityAbstract Renorrhaphy is often performed after tumor resection during robotic-assisted laparoscopic partial nephrectomy (RAPN). This study aimed to investigate the association between renorrhaphy performance and inflammatory markers. A retrospective cohort study was conducted including patients with renal cell carcinoma who underwent RAPN at eight institutions in Japan between April 2016 and November 2023. The primary endpoint was the association between the renorrhaphy performance in RAPN and the postoperative inflammatory markers. The secondary endpoints were perioperative outcomes in patients with and without renorrhaphy. The patients were divided into two groups at the time of RAPN: those who underwent renorrhaphy (renorrhaphy group) and those who did not (omitted group). In total, 934 patients were enrolled in this study. After propensity score matching, the rate of change in C-reactive protein and neutrophil-lymphocyte ratio on postoperative day 28 were not significant difference between the two groups. In contrast, the rate of change in platelet-lymphocyte ratio (PLR) on postoperative day 28 was significantly higher in renorrhaphy group than omitted group. Regarding surgical outcomes, the renorrhaphy group had a significantly longer hospital stay, operative time, and warm ischemia time (P = 0.038, P = 0.022, and P = 0.009, respectively) than the omitted group did. Furthermore, the omitted group had a significantly higher rate of Trifecta achievement than the renorrhaphy group did. This study demonstrated that renorrhaphy performance in RAPN was significantly associated with the higher value of postoperative PLR.https://doi.org/10.1038/s41598-024-82197-xRenal cell carcinomaRobot-assisted partial nephrectomyRenorrhaphyPlatelet-to-lymphocyte ratio |
| spellingShingle | Tomoki Taniguchi Kentaro Muraoka Kohei Nishikawa Yoshinori Ikehata Kiyoshi Setoguchi Suguru Oka Shin Ebara Akira Fujisaki Kazuhide Makiyama Takahiro Inoue Hiroshi Kitamura Kazutaka Saito Shinji Urakami Tatsuaki Yoneda Takuya Koie Impact of platelet-lymphocyte ratio after robot-assisted partial nephrectomy with renorrhaphy Scientific Reports Renal cell carcinoma Robot-assisted partial nephrectomy Renorrhaphy Platelet-to-lymphocyte ratio |
| title | Impact of platelet-lymphocyte ratio after robot-assisted partial nephrectomy with renorrhaphy |
| title_full | Impact of platelet-lymphocyte ratio after robot-assisted partial nephrectomy with renorrhaphy |
| title_fullStr | Impact of platelet-lymphocyte ratio after robot-assisted partial nephrectomy with renorrhaphy |
| title_full_unstemmed | Impact of platelet-lymphocyte ratio after robot-assisted partial nephrectomy with renorrhaphy |
| title_short | Impact of platelet-lymphocyte ratio after robot-assisted partial nephrectomy with renorrhaphy |
| title_sort | impact of platelet lymphocyte ratio after robot assisted partial nephrectomy with renorrhaphy |
| topic | Renal cell carcinoma Robot-assisted partial nephrectomy Renorrhaphy Platelet-to-lymphocyte ratio |
| url | https://doi.org/10.1038/s41598-024-82197-x |
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