The Nuclear Receptor NR1B1/RARα Arrests the Differentiation of Anti‐Tumor Effector Cytotoxic T Cells

The Nuclear Receptor NR1B1/RARα Arrests the Differentiation of Anti‐Tumor Effector Cytotoxic T Cells

Abstract NR1B1/RARα expression is dynamically regulated in cytotoxic lymphocytes (CTLs) in tumors, but the importance of its expression in anti‐tumor CTLs remains unknown. RARα gene expression is upregulated in CTLs in tumor microenvironments (TME), but its protein expression is downregulated by ret...

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Bibliographic Details
Main Authors: Patrick Niekamp, Ryun Hee Kim, Adithyan Jayaraman, Nils Klement, Raymond Kostlan, Chang H. Kim
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Advanced Science
Subjects:
BATF
CD8 T cells
histone deacetylase
RARα
retinoic acid
trafficking receptor switch
Online Access:https://doi.org/10.1002/advs.202410241
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