Recent advances in (4 + 3) cycloaddition of allenes

Allenes are a class of unsaturated compounds containing a propadiene structural moiety, exhibiting essential physiological, pharmacological, and various reactivities. Their (4 ​+ ​3) cycloaddition reaction has become an effective method for synthesizing seven-membered rings, especially for heterocyc...

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Main Authors: Yanyan Que, Wenli Lei, Yin Fang, Shuzhong He, Yang Chen
Format: Article
Language:English
Published: KeAi Communications Co. Ltd. 2024-11-01
Series:Green Synthesis and Catalysis
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Online Access:http://www.sciencedirect.com/science/article/pii/S2666554923001047
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author Yanyan Que
Wenli Lei
Yin Fang
Shuzhong He
Yang Chen
author_facet Yanyan Que
Wenli Lei
Yin Fang
Shuzhong He
Yang Chen
author_sort Yanyan Que
collection DOAJ
description Allenes are a class of unsaturated compounds containing a propadiene structural moiety, exhibiting essential physiological, pharmacological, and various reactivities. Their (4 ​+ ​3) cycloaddition reaction has become an effective method for synthesizing seven-membered rings, especially for heterocycles. This method has been continuously improved and developed. Herein, we review the (4 ​+ ​3) cycloaddition of allenes, focusing on the developed methodologies and the outlook in this field from 2013 to 2023.
format Article
id doaj-art-ec2a153e5f8a4f6d9848c78b1bcea55f
institution Kabale University
issn 2666-5549
language English
publishDate 2024-11-01
publisher KeAi Communications Co. Ltd.
record_format Article
series Green Synthesis and Catalysis
spelling doaj-art-ec2a153e5f8a4f6d9848c78b1bcea55f2024-11-30T07:14:17ZengKeAi Communications Co. Ltd.Green Synthesis and Catalysis2666-55492024-11-0154270276Recent advances in (4 + 3) cycloaddition of allenesYanyan Que0Wenli Lei1Yin Fang2Shuzhong He3Yang Chen4School of Pharmaceutical Sciences, Guizhou Engineering Laboratory for Synthetic Drugs, Guizhou University, Guiyan 550025, ChinaSchool of Pharmaceutical Sciences, Guizhou Engineering Laboratory for Synthetic Drugs, Guizhou University, Guiyan 550025, ChinaSchool of Pharmaceutical Sciences, Guizhou Engineering Laboratory for Synthetic Drugs, Guizhou University, Guiyan 550025, ChinaSchool of Pharmaceutical Sciences, Guizhou Engineering Laboratory for Synthetic Drugs, Guizhou University, Guiyan 550025, China; Corresponding author.School of Pharmaceutical Sciences, Guizhou Engineering Laboratory for Synthetic Drugs, Guizhou University, Guiyan 550025, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China; Corresponding author.Allenes are a class of unsaturated compounds containing a propadiene structural moiety, exhibiting essential physiological, pharmacological, and various reactivities. Their (4 ​+ ​3) cycloaddition reaction has become an effective method for synthesizing seven-membered rings, especially for heterocycles. This method has been continuously improved and developed. Herein, we review the (4 ​+ ​3) cycloaddition of allenes, focusing on the developed methodologies and the outlook in this field from 2013 to 2023.http://www.sciencedirect.com/science/article/pii/S2666554923001047Allenes(4 + 3) CycloadditionAsymmetric catalysisSeven-membered heterocycles
spellingShingle Yanyan Que
Wenli Lei
Yin Fang
Shuzhong He
Yang Chen
Recent advances in (4 + 3) cycloaddition of allenes
Green Synthesis and Catalysis
Allenes
(4 + 3) Cycloaddition
Asymmetric catalysis
Seven-membered heterocycles
title Recent advances in (4 + 3) cycloaddition of allenes
title_full Recent advances in (4 + 3) cycloaddition of allenes
title_fullStr Recent advances in (4 + 3) cycloaddition of allenes
title_full_unstemmed Recent advances in (4 + 3) cycloaddition of allenes
title_short Recent advances in (4 + 3) cycloaddition of allenes
title_sort recent advances in 4 3 cycloaddition of allenes
topic Allenes
(4 + 3) Cycloaddition
Asymmetric catalysis
Seven-membered heterocycles
url http://www.sciencedirect.com/science/article/pii/S2666554923001047
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AT wenlilei recentadvancesin43cycloadditionofallenes
AT yinfang recentadvancesin43cycloadditionofallenes
AT shuzhonghe recentadvancesin43cycloadditionofallenes
AT yangchen recentadvancesin43cycloadditionofallenes