Modulation of epileptogenesis through transplantation of human mesenchymal stem cells with or without GDNF release

Modulation of epileptogenesis through transplantation of human mesenchymal stem cells with or without GDNF release

Abstract Epilepsy is a central nervous system disorder causing uncontrollable seizures. One-third of patients do not respond to current medications, necessitating new treatments. This study targeted epileptogenesis, the process leading to chronic epilepsy, using human mesenchymal stem cells (MSCs) i...

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Bibliographic Details
Main Authors: Eliška Waloschková, Esbjörn Melin, Camille Baumlin, My Andersson, Alberto Martínez Serrano, Merab Kokaia, Marco Ledri
Format: Article
Language:English
Published: Springer 2025-08-01
Series:Cellular and Molecular Life Sciences
Subjects:
Human mesenchymal stem cells
GDNF
Epileptogenesis
Epilepsy
Inflammation
Online Access:https://doi.org/10.1007/s00018-025-05853-z
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