A Tympanic Piezo‐Bioreactor Modulates Ion Channel‐Associated Mechanosignaling to Stabilize Phenotype and Promote Tenogenesis in Human Tendon‐Derived Cells.

A Tympanic Piezo‐Bioreactor Modulates Ion Channel‐Associated Mechanosignaling to Stabilize Phenotype and Promote Tenogenesis in Human Tendon‐Derived Cells.

Abstract Preserving the function of human tendon‐derived cells (hTDCs) during cell expansion is a significant challenge in regenerative medicine. In this study, a non‐genetic approach is introduced to control the differentiation of hTDCs using a newly developed tympanic bioreactor. The system mimics...

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Bibliographic Details
Main Authors: Marc A. Fernandez‐Yague, Matteo Palma, Syed A. M. Tofail, Maeve Duffy, Leo R. Quinlan, Mathew J. Dalby, Abhay Pandit, Manus J. Biggs
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
BNNT
electromechanical
FAK
focal adhesions
mechanotransduction
piezoelectricity
Online Access:https://doi.org/10.1002/advs.202405711
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https://doi.org/10.1002/advs.202405711

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