A case of hemorrhagic fever with renal syndrome and abnormal serum levels of ferritin, vitamin B12, and folic acid
Introduction: Hemorrhagic fever with renal syndrome (HFRS) is a globally prevalent infectious disease caused by the hantavirus in rodents. Case study: This report describes a case of a 36-year-old male presenting with elevated ferritin, vitamin B12, and folic acid deficiency during the early onse...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Journal of Infection in Developing Countries
2024-01-01
|
| Series: | Journal of Infection in Developing Countries |
| Subjects: | |
| Online Access: | https://jidc.org/index.php/journal/article/view/18541 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849313611667734528 |
|---|---|
| author | Yiyun Ni Bin Liu Weizhen Zhang Shengwen Shi Jianchao Deng |
| author_facet | Yiyun Ni Bin Liu Weizhen Zhang Shengwen Shi Jianchao Deng |
| author_sort | Yiyun Ni |
| collection | DOAJ |
| description |
Introduction: Hemorrhagic fever with renal syndrome (HFRS) is a globally prevalent infectious disease caused by the hantavirus in rodents.
Case study: This report describes a case of a 36-year-old male presenting with elevated ferritin, vitamin B12, and folic acid deficiency during the early onset phase of HFRS. Despite normal renal function at admission, the patient exhibited persistent fever and thrombocytopenia, leading to a potential misdiagnosis of an atypical HFRS presentation. Abnormal serum levels of ferritin, vitamin B12, and folic acid served as early indicators of renal dysfunction in patients with HRFS. The patient's condition improved rapidly with a combination of vitamin B6, methyl cobalamin, and folic acid, as evidenced by a subsequent decrease in the ferritin levels, from 3000 to 600 ng/mL, on days 4 and 24, respectively, and an increase in the vitamin B12 and folic acid levels to 200 pg/mL and 36.7 ng/mL, separately.
Conclusions: These findings suggest that ferritin, vitamin B12, and folic acid have the potential to serve as biomarkers for HFRS and play a predictive role in the diagnosis and treatment of the disease.
|
| format | Article |
| id | doaj-art-ec088fc46f244550bdbb74ee71be5ad7 |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-ec088fc46f244550bdbb74ee71be5ad72025-08-20T03:52:42ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802024-01-01180110.3855/jidc.18541A case of hemorrhagic fever with renal syndrome and abnormal serum levels of ferritin, vitamin B12, and folic acidYiyun Ni0Bin Liu1Weizhen Zhang2Shengwen Shi3Jianchao Deng4The Central Hospital of Yongzhou, Yongzhou Clinical College, University of South China, Yongzhou, Hunan Province, 425000, ChinaThe Central Hospital of Yongzhou, Yongzhou Clinical College, University of South China, Yongzhou, Hunan Province, 425000, ChinaThe Central Hospital of Yongzhou, Yongzhou Clinical College, University of South China, Yongzhou, Hunan Province, 425000, ChinaThe Central Hospital of Yongzhou, Yongzhou Clinical College, University of South China, Yongzhou, Hunan Province, 425000, ChinaThe Central Hospital of Yongzhou, Yongzhou Clinical College, University of South China, Yongzhou, Hunan Province, 425000, China Introduction: Hemorrhagic fever with renal syndrome (HFRS) is a globally prevalent infectious disease caused by the hantavirus in rodents. Case study: This report describes a case of a 36-year-old male presenting with elevated ferritin, vitamin B12, and folic acid deficiency during the early onset phase of HFRS. Despite normal renal function at admission, the patient exhibited persistent fever and thrombocytopenia, leading to a potential misdiagnosis of an atypical HFRS presentation. Abnormal serum levels of ferritin, vitamin B12, and folic acid served as early indicators of renal dysfunction in patients with HRFS. The patient's condition improved rapidly with a combination of vitamin B6, methyl cobalamin, and folic acid, as evidenced by a subsequent decrease in the ferritin levels, from 3000 to 600 ng/mL, on days 4 and 24, respectively, and an increase in the vitamin B12 and folic acid levels to 200 pg/mL and 36.7 ng/mL, separately. Conclusions: These findings suggest that ferritin, vitamin B12, and folic acid have the potential to serve as biomarkers for HFRS and play a predictive role in the diagnosis and treatment of the disease. https://jidc.org/index.php/journal/article/view/18541HFRSferritinvitamin B12folic acid |
| spellingShingle | Yiyun Ni Bin Liu Weizhen Zhang Shengwen Shi Jianchao Deng A case of hemorrhagic fever with renal syndrome and abnormal serum levels of ferritin, vitamin B12, and folic acid Journal of Infection in Developing Countries HFRS ferritin vitamin B12 folic acid |
| title | A case of hemorrhagic fever with renal syndrome and abnormal serum levels of ferritin, vitamin B12, and folic acid |
| title_full | A case of hemorrhagic fever with renal syndrome and abnormal serum levels of ferritin, vitamin B12, and folic acid |
| title_fullStr | A case of hemorrhagic fever with renal syndrome and abnormal serum levels of ferritin, vitamin B12, and folic acid |
| title_full_unstemmed | A case of hemorrhagic fever with renal syndrome and abnormal serum levels of ferritin, vitamin B12, and folic acid |
| title_short | A case of hemorrhagic fever with renal syndrome and abnormal serum levels of ferritin, vitamin B12, and folic acid |
| title_sort | case of hemorrhagic fever with renal syndrome and abnormal serum levels of ferritin vitamin b12 and folic acid |
| topic | HFRS ferritin vitamin B12 folic acid |
| url | https://jidc.org/index.php/journal/article/view/18541 |
| work_keys_str_mv | AT yiyunni acaseofhemorrhagicfeverwithrenalsyndromeandabnormalserumlevelsofferritinvitaminb12andfolicacid AT binliu acaseofhemorrhagicfeverwithrenalsyndromeandabnormalserumlevelsofferritinvitaminb12andfolicacid AT weizhenzhang acaseofhemorrhagicfeverwithrenalsyndromeandabnormalserumlevelsofferritinvitaminb12andfolicacid AT shengwenshi acaseofhemorrhagicfeverwithrenalsyndromeandabnormalserumlevelsofferritinvitaminb12andfolicacid AT jianchaodeng acaseofhemorrhagicfeverwithrenalsyndromeandabnormalserumlevelsofferritinvitaminb12andfolicacid AT yiyunni caseofhemorrhagicfeverwithrenalsyndromeandabnormalserumlevelsofferritinvitaminb12andfolicacid AT binliu caseofhemorrhagicfeverwithrenalsyndromeandabnormalserumlevelsofferritinvitaminb12andfolicacid AT weizhenzhang caseofhemorrhagicfeverwithrenalsyndromeandabnormalserumlevelsofferritinvitaminb12andfolicacid AT shengwenshi caseofhemorrhagicfeverwithrenalsyndromeandabnormalserumlevelsofferritinvitaminb12andfolicacid AT jianchaodeng caseofhemorrhagicfeverwithrenalsyndromeandabnormalserumlevelsofferritinvitaminb12andfolicacid |