Proteomic profiling identifies a stromal TGF-β1/podoplanin axis as a driver of colorectal cancer progression

Proteomic profiling identifies a stromal TGF-β1/podoplanin axis as a driver of colorectal cancer progression

Abstract Background The tumor microenvironment (TME) plays a pivotal role in the development and progression of colorectal cancer (CRC), yet the complex crosstalk among its components remains incompletely understood. Cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs) have e...

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Main Authors: Silvia Di Agostino, Davide La Padula, Vittoria Rago, Caterina Gabriele, Francesco Conforti, Elio Aprigliano, Lidia Urlandini, Elvira Parrotta, Danilo Lofaro, Francesca Vescio, Andrea Sacconi, Valeria Cernaro, Giuseppe Currò, Angela Alibrandi, Girolamo Ranieri, Valeria Zuccalà, Antonio Ieni, Marco Gaspari, Giovanni Cuda, Michele Ammendola, Vittorio Abbonante
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Colorectal cancer
Tumor microenvironment
Proteomic
Tumor associated macrophages
Cancer associated fibroblasts
Transforming growth factor beta
Online Access:https://doi.org/10.1186/s13046-025-03496-3
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https://doi.org/10.1186/s13046-025-03496-3

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