1,2-Oxidative Trifluoromethylation of Olefin with Ag(O<sub>2</sub>CCF<sub>2</sub>SO<sub>2</sub>F) and O<sub>2</sub>: Synthesis of α-Trifluoromethyl Ketones
A novel and efficient 1,2-oxidative trifluoromethylation of olefins employing Ag(O<sub>2</sub>CCF<sub>2</sub>SO<sub>2</sub>F) as a trifluoromethyl source is described with O<sub>2</sub> as the oxidant, which provides access to a variety of valuable α-t...
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2024-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/23/5622 |
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| author | Shengxue Zhang Wangchuan Xiao Jingjing Wu Fanhong Wu Houjin Huang Xiaoyu Ma Yafei Shi Chao Liu |
| author_facet | Shengxue Zhang Wangchuan Xiao Jingjing Wu Fanhong Wu Houjin Huang Xiaoyu Ma Yafei Shi Chao Liu |
| author_sort | Shengxue Zhang |
| collection | DOAJ |
| description | A novel and efficient 1,2-oxidative trifluoromethylation of olefins employing Ag(O<sub>2</sub>CCF<sub>2</sub>SO<sub>2</sub>F) as a trifluoromethyl source is described with O<sub>2</sub> as the oxidant, which provides access to a variety of valuable α-trifluoromethyl-substituted ketones. The broad substrate scope, feasibility of large-scale operation, and derivatization reactions of α-trifluoromethyl ketones demonstrate the promising utility of this protocol. |
| format | Article |
| id | doaj-art-ebf39945ddad4080b7dc368f0f4d5ffb |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-ebf39945ddad4080b7dc368f0f4d5ffb2024-12-13T16:28:29ZengMDPI AGMolecules1420-30492024-11-012923562210.3390/molecules292356221,2-Oxidative Trifluoromethylation of Olefin with Ag(O<sub>2</sub>CCF<sub>2</sub>SO<sub>2</sub>F) and O<sub>2</sub>: Synthesis of α-Trifluoromethyl KetonesShengxue Zhang0Wangchuan Xiao1Jingjing Wu2Fanhong Wu3Houjin Huang4Xiaoyu Ma5Yafei Shi6Chao Liu7School of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, ChinaShanghai-Sanming Engineering Research Center of Green Fluoropharmaceutical Technology, 25 Jingdong Road, Sanming 365004, ChinaSchool of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, ChinaSchool of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, ChinaSchool of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, ChinaSchool of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, ChinaSchool of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, ChinaSchool of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, ChinaA novel and efficient 1,2-oxidative trifluoromethylation of olefins employing Ag(O<sub>2</sub>CCF<sub>2</sub>SO<sub>2</sub>F) as a trifluoromethyl source is described with O<sub>2</sub> as the oxidant, which provides access to a variety of valuable α-trifluoromethyl-substituted ketones. The broad substrate scope, feasibility of large-scale operation, and derivatization reactions of α-trifluoromethyl ketones demonstrate the promising utility of this protocol.https://www.mdpi.com/1420-3049/29/23/5622Ag(O<sub>2</sub>CCF<sub>2</sub>SO<sub>2</sub>F)trifluoromethylationα-trifluoromethyl ketones |
| spellingShingle | Shengxue Zhang Wangchuan Xiao Jingjing Wu Fanhong Wu Houjin Huang Xiaoyu Ma Yafei Shi Chao Liu 1,2-Oxidative Trifluoromethylation of Olefin with Ag(O<sub>2</sub>CCF<sub>2</sub>SO<sub>2</sub>F) and O<sub>2</sub>: Synthesis of α-Trifluoromethyl Ketones Molecules Ag(O<sub>2</sub>CCF<sub>2</sub>SO<sub>2</sub>F) trifluoromethylation α-trifluoromethyl ketones |
| title | 1,2-Oxidative Trifluoromethylation of Olefin with Ag(O<sub>2</sub>CCF<sub>2</sub>SO<sub>2</sub>F) and O<sub>2</sub>: Synthesis of α-Trifluoromethyl Ketones |
| title_full | 1,2-Oxidative Trifluoromethylation of Olefin with Ag(O<sub>2</sub>CCF<sub>2</sub>SO<sub>2</sub>F) and O<sub>2</sub>: Synthesis of α-Trifluoromethyl Ketones |
| title_fullStr | 1,2-Oxidative Trifluoromethylation of Olefin with Ag(O<sub>2</sub>CCF<sub>2</sub>SO<sub>2</sub>F) and O<sub>2</sub>: Synthesis of α-Trifluoromethyl Ketones |
| title_full_unstemmed | 1,2-Oxidative Trifluoromethylation of Olefin with Ag(O<sub>2</sub>CCF<sub>2</sub>SO<sub>2</sub>F) and O<sub>2</sub>: Synthesis of α-Trifluoromethyl Ketones |
| title_short | 1,2-Oxidative Trifluoromethylation of Olefin with Ag(O<sub>2</sub>CCF<sub>2</sub>SO<sub>2</sub>F) and O<sub>2</sub>: Synthesis of α-Trifluoromethyl Ketones |
| title_sort | 1 2 oxidative trifluoromethylation of olefin with ag o sub 2 sub ccf sub 2 sub so sub 2 sub f and o sub 2 sub synthesis of α trifluoromethyl ketones |
| topic | Ag(O<sub>2</sub>CCF<sub>2</sub>SO<sub>2</sub>F) trifluoromethylation α-trifluoromethyl ketones |
| url | https://www.mdpi.com/1420-3049/29/23/5622 |
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