1,2-Oxidative Trifluoromethylation of Olefin with Ag(O<sub>2</sub>CCF<sub>2</sub>SO<sub>2</sub>F) and O<sub>2</sub>: Synthesis of α-Trifluoromethyl Ketones
A novel and efficient 1,2-oxidative trifluoromethylation of olefins employing Ag(O<sub>2</sub>CCF<sub>2</sub>SO<sub>2</sub>F) as a trifluoromethyl source is described with O<sub>2</sub> as the oxidant, which provides access to a variety of valuable α-t...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/29/23/5622 |
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| Summary: | A novel and efficient 1,2-oxidative trifluoromethylation of olefins employing Ag(O<sub>2</sub>CCF<sub>2</sub>SO<sub>2</sub>F) as a trifluoromethyl source is described with O<sub>2</sub> as the oxidant, which provides access to a variety of valuable α-trifluoromethyl-substituted ketones. The broad substrate scope, feasibility of large-scale operation, and derivatization reactions of α-trifluoromethyl ketones demonstrate the promising utility of this protocol. |
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| ISSN: | 1420-3049 |