Correlates of mental health of people living with HIV co-infected with SARS-CoV-2: findings from the COVIDHIV study in France
BackgroundThe COVID-19 pandemic has severely affected vulnerable populations, especially individuals living with HIV/AIDS (PLWHA). The convergence of HIV/AIDS and COVID-19 presents unique challenges, exacerbating existing health concerns and magnifying the strain on individuals already grappling wit...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1437362/full |
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| author | Issifou Yaya Issifou Yaya Yvenie Amboise Yvenie Amboise Guillaume Roucoux Guillaume Roucoux Lisa Yombo-Kokule Lisa Yombo-Kokule Fabienne Marcellin Claudine Duvivier Claudine Duvivier Karine Lacombe Karine Lacombe James W. Griffith James W. Griffith Marie Préau Antoine Cheret Antoine Cheret Martin Duracinsky Martin Duracinsky Martin Duracinsky |
| author_facet | Issifou Yaya Issifou Yaya Yvenie Amboise Yvenie Amboise Guillaume Roucoux Guillaume Roucoux Lisa Yombo-Kokule Lisa Yombo-Kokule Fabienne Marcellin Claudine Duvivier Claudine Duvivier Karine Lacombe Karine Lacombe James W. Griffith James W. Griffith Marie Préau Antoine Cheret Antoine Cheret Martin Duracinsky Martin Duracinsky Martin Duracinsky |
| author_sort | Issifou Yaya |
| collection | DOAJ |
| description | BackgroundThe COVID-19 pandemic has severely affected vulnerable populations, especially individuals living with HIV/AIDS (PLWHA). The convergence of HIV/AIDS and COVID-19 presents unique challenges, exacerbating existing health concerns and magnifying the strain on individuals already grappling with compromised immune systems. This study aimed to investigate the mental well-being repercussions faced by PLWHA co-infected with SARS-CoV-2 in France.MethodsCOVIDHIV is a French multicenter cohort of PLWHA co-infected with SARS-CoV-2, which collected sociodemographic, clinical, and mental health data. Anxiety and depression symptoms and post-traumatic stress disorder (PTSD) were assessed by the Hospital Anxiety and Depression Scale (HADS) and the PTSD Checklist (PCL-S), respectively. Multivariable logistic regression was performed to identify factors associated with mental health outcomes at inclusion in the cohort.ResultsOf the 397 participants included, 64.7% were male. The mean age was 51.6 (± 11.8) years. The prevalence of mental health outcomes was 33.5% ([95%CI: 28.5-39.0%]) for anxiety, 21.0% ([16.8-25.9%]) for depression, and 12.2% ([8.9-16.5%]) for PTSD. In multivariable regression adjusted for sex, COVID-19 wave and duration between COVID-19 confirmation and enrolment, age (adjusted odds-ratio (aOR): 0.97 [0.95-0.99]), being professionally active (0.43 [0.25-0.75]), and the number of self-reported symptoms (1.17 [1.11-1.24]) were associated with anxiety. Being professionally active (0.34 [0.18-0.65]), living in a couple (0.52 [0.20-0.98]), number of self-reported symptoms (1.15 [1.08-1.22]), and hospitalization for COVID-19 (3.35 [1.34-8.33]) were associated with depression. The number of self-reported symptoms (1.27 [1.16-1.41]), psychiatric disorders (4.04 [1.48-11.11]), and perceived vulnerability to COVID-19 (4.53 [1.69-14.60]) were associated with PTSD.ConclusionThe mental health is a challenging issue among the participants and needs to be closely monitored among people already affected by a chronic disease such as HIV. The findings underscore the urgent need for targeted support and interventions tailored to address the mental health needs of PLWHA facing the dual burden of HIV/AIDS and COVID-19. |
| format | Article |
| id | doaj-art-ebf157aa769e46b7b97f2cc780971f56 |
| institution | Kabale University |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-ebf157aa769e46b7b97f2cc780971f562025-01-03T06:47:16ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-01-011510.3389/fpsyt.2024.14373621437362Correlates of mental health of people living with HIV co-infected with SARS-CoV-2: findings from the COVIDHIV study in FranceIssifou Yaya0Issifou Yaya1Yvenie Amboise2Yvenie Amboise3Guillaume Roucoux4Guillaume Roucoux5Lisa Yombo-Kokule6Lisa Yombo-Kokule7Fabienne Marcellin8Claudine Duvivier9Claudine Duvivier10Karine Lacombe11Karine Lacombe12James W. Griffith13James W. Griffith14Marie Préau15Antoine Cheret16Antoine Cheret17Martin Duracinsky18Martin Duracinsky19Martin Duracinsky20Patient-Reported Outcomes Research (PROQOL), Health Economics Clinical Trial Unit (URC-ECO), Hotel-Dieu Hospital, AP- HP, Paris, FranceECEVE, UMR-S 1123, Paris Cité University, Inserm, Paris, FrancePatient-Reported Outcomes Research (PROQOL), Health Economics Clinical Trial Unit (URC-ECO), Hotel-Dieu Hospital, AP- HP, Paris, FranceECEVE, UMR-S 1123, Paris Cité University, Inserm, Paris, FrancePatient-Reported Outcomes Research (PROQOL), Health Economics Clinical Trial Unit (URC-ECO), Hotel-Dieu Hospital, AP- HP, Paris, FranceECEVE, UMR-S 1123, Paris Cité University, Inserm, Paris, FrancePatient-Reported Outcomes Research (PROQOL), Health Economics Clinical Trial Unit (URC-ECO), Hotel-Dieu Hospital, AP- HP, Paris, FranceECEVE, UMR-S 1123, Paris Cité University, Inserm, Paris, FranceAix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques et Sociales de la Santé et Traitement de l’Information Médicale, ISSPAM, Marseille, FranceParis Cité University, Necker Hospital, AP-HP, Infectious Diseases Department, Necker-Pasteur Infectiology Center, Paris, FranceInserm U1016, CNRS UMR 8104, Université Paris Descartes, Institut Cochin, Paris, FranceHôpital Saint-Antoine, Assistance Publique Des Hôpitaux de Paris, Service Des Maladies Infectieuses Et Tropicales, Cedex 12, Paris, FranceINSERM, Pierre Louis Institute of Epidemiology and Public Health (IPLESP), Sorbonne University, Paris, FranceDepartment of Obstetrics and Gynecology, Biological Sciences Division, The University of Chicago, Chicago, IL, United StatesDepartment of Psychiatry and Behavioral Neuroscience, Biological Sciences Division, The University of Chicago, Chicago, IL, United States0Inserm Unit 1296 « Radiations: Defense, Health, Environment »; Lyon 2 Lumière University, Lyon, France1Plateforme de Diagnostic et de Thérapeutique Pluridisciplinaire, CHU, Guadeloupe, France2INSERM, U1016, CNRS, UMR8104, Institut Cochin, Paris, FrancePatient-Reported Outcomes Research (PROQOL), Health Economics Clinical Trial Unit (URC-ECO), Hotel-Dieu Hospital, AP- HP, Paris, FranceECEVE, UMR-S 1123, Paris Cité University, Inserm, Paris, France3Internal Medicine Unit, Le Kremlin Bicêtre Hospital, Bicêtre, FranceBackgroundThe COVID-19 pandemic has severely affected vulnerable populations, especially individuals living with HIV/AIDS (PLWHA). The convergence of HIV/AIDS and COVID-19 presents unique challenges, exacerbating existing health concerns and magnifying the strain on individuals already grappling with compromised immune systems. This study aimed to investigate the mental well-being repercussions faced by PLWHA co-infected with SARS-CoV-2 in France.MethodsCOVIDHIV is a French multicenter cohort of PLWHA co-infected with SARS-CoV-2, which collected sociodemographic, clinical, and mental health data. Anxiety and depression symptoms and post-traumatic stress disorder (PTSD) were assessed by the Hospital Anxiety and Depression Scale (HADS) and the PTSD Checklist (PCL-S), respectively. Multivariable logistic regression was performed to identify factors associated with mental health outcomes at inclusion in the cohort.ResultsOf the 397 participants included, 64.7% were male. The mean age was 51.6 (± 11.8) years. The prevalence of mental health outcomes was 33.5% ([95%CI: 28.5-39.0%]) for anxiety, 21.0% ([16.8-25.9%]) for depression, and 12.2% ([8.9-16.5%]) for PTSD. In multivariable regression adjusted for sex, COVID-19 wave and duration between COVID-19 confirmation and enrolment, age (adjusted odds-ratio (aOR): 0.97 [0.95-0.99]), being professionally active (0.43 [0.25-0.75]), and the number of self-reported symptoms (1.17 [1.11-1.24]) were associated with anxiety. Being professionally active (0.34 [0.18-0.65]), living in a couple (0.52 [0.20-0.98]), number of self-reported symptoms (1.15 [1.08-1.22]), and hospitalization for COVID-19 (3.35 [1.34-8.33]) were associated with depression. The number of self-reported symptoms (1.27 [1.16-1.41]), psychiatric disorders (4.04 [1.48-11.11]), and perceived vulnerability to COVID-19 (4.53 [1.69-14.60]) were associated with PTSD.ConclusionThe mental health is a challenging issue among the participants and needs to be closely monitored among people already affected by a chronic disease such as HIV. The findings underscore the urgent need for targeted support and interventions tailored to address the mental health needs of PLWHA facing the dual burden of HIV/AIDS and COVID-19.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1437362/fullCOVID-19HIVanxietydepressionpost-traumatic stress disordermental health |
| spellingShingle | Issifou Yaya Issifou Yaya Yvenie Amboise Yvenie Amboise Guillaume Roucoux Guillaume Roucoux Lisa Yombo-Kokule Lisa Yombo-Kokule Fabienne Marcellin Claudine Duvivier Claudine Duvivier Karine Lacombe Karine Lacombe James W. Griffith James W. Griffith Marie Préau Antoine Cheret Antoine Cheret Martin Duracinsky Martin Duracinsky Martin Duracinsky Correlates of mental health of people living with HIV co-infected with SARS-CoV-2: findings from the COVIDHIV study in France Frontiers in Psychiatry COVID-19 HIV anxiety depression post-traumatic stress disorder mental health |
| title | Correlates of mental health of people living with HIV co-infected with SARS-CoV-2: findings from the COVIDHIV study in France |
| title_full | Correlates of mental health of people living with HIV co-infected with SARS-CoV-2: findings from the COVIDHIV study in France |
| title_fullStr | Correlates of mental health of people living with HIV co-infected with SARS-CoV-2: findings from the COVIDHIV study in France |
| title_full_unstemmed | Correlates of mental health of people living with HIV co-infected with SARS-CoV-2: findings from the COVIDHIV study in France |
| title_short | Correlates of mental health of people living with HIV co-infected with SARS-CoV-2: findings from the COVIDHIV study in France |
| title_sort | correlates of mental health of people living with hiv co infected with sars cov 2 findings from the covidhiv study in france |
| topic | COVID-19 HIV anxiety depression post-traumatic stress disorder mental health |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1437362/full |
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