Review on regulatory role of morphogens in the formation of dorsal-ventral pattern of vertebrate neural tube
In vertebrates, the development of the central nervous system depends on the correct patterning of the neural tube along its anterior-posterior and dorsal-ventral axes in the early embryo as well as the underlying regulation of the cell differentiation. During the neural tube formation, the arrangem...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Zhejiang University Press
2022-10-01
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| Series: | 浙江大学学报. 农业与生命科学版 |
| Subjects: | |
| Online Access: | https://www.academax.com/doi/10.3785/j.issn.1008-9209.2021.09.231 |
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| Summary: | In vertebrates, the development of the central nervous system depends on the correct patterning of the neural tube along its anterior-posterior and dorsal-ventral axes in the early embryo as well as the underlying regulation of the cell differentiation. During the neural tube formation, the arrangement of the precursor cells depends on the regulation of different morphogen concentration gradients. The most important morphogens during the neural tube development are the bone morphogenetic protein (BMP) secreted from the roof plate and the Sonic hedgehog (Shh) secreted from the floor plate, which would form an antiparallel concentration gradient in the neural tube. These morphogen concentration gradients could further provide the positional information to the precursor cells and gradually determine their differentiation fate. In this paper, we summarized the process of neural tube development in different model organisms, focusing on the important role of two morphogens of BMP and Shh in the formation of dorsal-ventral pattern of the neural tube. Besides, a better understanding of the developmental mechanism of the nervous system in vivo would also provide some insights on the construction of neural tube organoids in vitro. Therefore, we also pointed out the latest progress of neural tube organoids and discussed the future perspective of this field. |
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| ISSN: | 1008-9209 2097-5155 |