Mechanism of action of “cistanche deserticola–Polygala” in treating Alzheimer's disease based on network pharmacology methods and molecular docking analysis
Abstract This article used network pharmacology, molecular docking, GEO analysis, and Gene Set Enrichment Analysis to obtain 38 main chemical components and 66 corresponding targets involved in Alzheimer's disease (AD) treatment in "Cistanche deserticola‐Polygala". Through further Gen...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | IET Systems Biology |
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| Online Access: | https://doi.org/10.1049/syb2.12100 |
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| author | Shaoqiang Wang Yifan Wang |
| author_facet | Shaoqiang Wang Yifan Wang |
| author_sort | Shaoqiang Wang |
| collection | DOAJ |
| description | Abstract This article used network pharmacology, molecular docking, GEO analysis, and Gene Set Enrichment Analysis to obtain 38 main chemical components and 66 corresponding targets involved in Alzheimer's disease (AD) treatment in "Cistanche deserticola‐Polygala". Through further Gene Ontology and Kyoto Encyclopaedia of Genes and Genomes enrichment analysis, we obtained AD signalling pathways, calcium signalling pathways, and other signalling pathways related to the treatment of AD with “Cistanche deserticola‐Polygala”. Molecular docking showed that most of the core chemical components had good binding ability with the core targets. This article aims to reveal the mechanism of “Cistanche deserticola‐Polygala” in treating AD and provide a basis for the treatment of AD with “Cistanche deserticola‐Polygala”. |
| format | Article |
| id | doaj-art-eb8e52c83e73412cacb7b65b57acd18d |
| institution | Kabale University |
| issn | 1751-8849 1751-8857 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | IET Systems Biology |
| spelling | doaj-art-eb8e52c83e73412cacb7b65b57acd18d2024-12-23T18:41:56ZengWileyIET Systems Biology1751-88491751-88572024-12-0118627128410.1049/syb2.12100Mechanism of action of “cistanche deserticola–Polygala” in treating Alzheimer's disease based on network pharmacology methods and molecular docking analysisShaoqiang Wang0Yifan Wang1School of Information and Control Engineering Qingdao University of Technology Qingdao ChinaThe Seventh Clinical Medical College Guangzhou University of Chinese Medicine Shenzhen ChinaAbstract This article used network pharmacology, molecular docking, GEO analysis, and Gene Set Enrichment Analysis to obtain 38 main chemical components and 66 corresponding targets involved in Alzheimer's disease (AD) treatment in "Cistanche deserticola‐Polygala". Through further Gene Ontology and Kyoto Encyclopaedia of Genes and Genomes enrichment analysis, we obtained AD signalling pathways, calcium signalling pathways, and other signalling pathways related to the treatment of AD with “Cistanche deserticola‐Polygala”. Molecular docking showed that most of the core chemical components had good binding ability with the core targets. This article aims to reveal the mechanism of “Cistanche deserticola‐Polygala” in treating AD and provide a basis for the treatment of AD with “Cistanche deserticola‐Polygala”.https://doi.org/10.1049/syb2.12100biocomputingbiocontrol |
| spellingShingle | Shaoqiang Wang Yifan Wang Mechanism of action of “cistanche deserticola–Polygala” in treating Alzheimer's disease based on network pharmacology methods and molecular docking analysis IET Systems Biology biocomputing biocontrol |
| title | Mechanism of action of “cistanche deserticola–Polygala” in treating Alzheimer's disease based on network pharmacology methods and molecular docking analysis |
| title_full | Mechanism of action of “cistanche deserticola–Polygala” in treating Alzheimer's disease based on network pharmacology methods and molecular docking analysis |
| title_fullStr | Mechanism of action of “cistanche deserticola–Polygala” in treating Alzheimer's disease based on network pharmacology methods and molecular docking analysis |
| title_full_unstemmed | Mechanism of action of “cistanche deserticola–Polygala” in treating Alzheimer's disease based on network pharmacology methods and molecular docking analysis |
| title_short | Mechanism of action of “cistanche deserticola–Polygala” in treating Alzheimer's disease based on network pharmacology methods and molecular docking analysis |
| title_sort | mechanism of action of cistanche deserticola polygala in treating alzheimer s disease based on network pharmacology methods and molecular docking analysis |
| topic | biocomputing biocontrol |
| url | https://doi.org/10.1049/syb2.12100 |
| work_keys_str_mv | AT shaoqiangwang mechanismofactionofcistanchedeserticolapolygalaintreatingalzheimersdiseasebasedonnetworkpharmacologymethodsandmoleculardockinganalysis AT yifanwang mechanismofactionofcistanchedeserticolapolygalaintreatingalzheimersdiseasebasedonnetworkpharmacologymethodsandmoleculardockinganalysis |