PI3K Mutation Profiles on Exons 9 (E545K and E542K) and 20 (H1047R) in Mexican Patients With HER-2 Overexpressed Breast Cancer and Its Relevance on Clinical–Pathological and Survival Biological Effects
Conclusion: Single and double-point mutations in PI3K are related to tumor size and advanced clinical–pathological traits in Mexican patients with HER-2 overexpression, and future molecular studies are necessary to understand these findings.
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2024/9058033 |
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| _version_ | 1841524394097115136 |
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| author | T. Nieto-Coronel Ortega-Gómez Alette R. Yacab E. A. Fernández-Figueroa C. Lopez-Camarillo L. Marchat H. Astudillo-de la Vega E. Ruiz-Garcia |
| author_facet | T. Nieto-Coronel Ortega-Gómez Alette R. Yacab E. A. Fernández-Figueroa C. Lopez-Camarillo L. Marchat H. Astudillo-de la Vega E. Ruiz-Garcia |
| author_sort | T. Nieto-Coronel |
| collection | DOAJ |
| description | Conclusion: Single and double-point mutations in PI3K are related to tumor size and advanced clinical–pathological traits in Mexican patients with HER-2 overexpression, and future molecular studies are necessary to understand these findings. |
| format | Article |
| id | doaj-art-eb452e007d104988872d8438a82a8a39 |
| institution | Kabale University |
| issn | 2090-3189 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-eb452e007d104988872d8438a82a8a392025-02-03T07:14:08ZengWileyInternational Journal of Breast Cancer2090-31892024-01-01202410.1155/2024/9058033PI3K Mutation Profiles on Exons 9 (E545K and E542K) and 20 (H1047R) in Mexican Patients With HER-2 Overexpressed Breast Cancer and Its Relevance on Clinical–Pathological and Survival Biological EffectsT. Nieto-Coronel0Ortega-Gómez Alette1R. Yacab2E. A. Fernández-Figueroa3C. Lopez-Camarillo4L. Marchat5H. Astudillo-de la Vega6E. Ruiz-Garcia7Medical Oncology UnitTranslational Medicine LaboratoryTranslational Medicine LaboratoryCore B of Innovation in Precision MedicinePosgrado en Ciencias GenómicasPrograma en Biomedicina Molecular y Red de BiotecnologíaTranslational Research Laboratory in Cancer & Cellular TherapyTranslational Medicine LaboratoryConclusion: Single and double-point mutations in PI3K are related to tumor size and advanced clinical–pathological traits in Mexican patients with HER-2 overexpression, and future molecular studies are necessary to understand these findings.http://dx.doi.org/10.1155/2024/9058033 |
| spellingShingle | T. Nieto-Coronel Ortega-Gómez Alette R. Yacab E. A. Fernández-Figueroa C. Lopez-Camarillo L. Marchat H. Astudillo-de la Vega E. Ruiz-Garcia PI3K Mutation Profiles on Exons 9 (E545K and E542K) and 20 (H1047R) in Mexican Patients With HER-2 Overexpressed Breast Cancer and Its Relevance on Clinical–Pathological and Survival Biological Effects International Journal of Breast Cancer |
| title | PI3K Mutation Profiles on Exons 9 (E545K and E542K) and 20 (H1047R) in Mexican Patients With HER-2 Overexpressed Breast Cancer and Its Relevance on Clinical–Pathological and Survival Biological Effects |
| title_full | PI3K Mutation Profiles on Exons 9 (E545K and E542K) and 20 (H1047R) in Mexican Patients With HER-2 Overexpressed Breast Cancer and Its Relevance on Clinical–Pathological and Survival Biological Effects |
| title_fullStr | PI3K Mutation Profiles on Exons 9 (E545K and E542K) and 20 (H1047R) in Mexican Patients With HER-2 Overexpressed Breast Cancer and Its Relevance on Clinical–Pathological and Survival Biological Effects |
| title_full_unstemmed | PI3K Mutation Profiles on Exons 9 (E545K and E542K) and 20 (H1047R) in Mexican Patients With HER-2 Overexpressed Breast Cancer and Its Relevance on Clinical–Pathological and Survival Biological Effects |
| title_short | PI3K Mutation Profiles on Exons 9 (E545K and E542K) and 20 (H1047R) in Mexican Patients With HER-2 Overexpressed Breast Cancer and Its Relevance on Clinical–Pathological and Survival Biological Effects |
| title_sort | pi3k mutation profiles on exons 9 e545k and e542k and 20 h1047r in mexican patients with her 2 overexpressed breast cancer and its relevance on clinical pathological and survival biological effects |
| url | http://dx.doi.org/10.1155/2024/9058033 |
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