Insulin resistance and lipid transport system in fasting normoglycemia
Aim. To investigate the link between insulin resistance (IR) and lipid transport system in patients with fasting normoglycemia. Material and methods. In 39 patients aged 2070 years, with fasting normoglycemia, the levels of lipids, apolipoproteins (apo), and IR parameters (insulin sensitivity index;...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
2007-10-01
|
| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1357 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849250729369272320 |
|---|---|
| author | O. V. Alexandrovich I. N. Ozerova N. V. Perova V. A. Metelskaya A. M. Olferyev G. N. Shchukina |
| author_facet | O. V. Alexandrovich I. N. Ozerova N. V. Perova V. A. Metelskaya A. M. Olferyev G. N. Shchukina |
| author_sort | O. V. Alexandrovich |
| collection | DOAJ |
| description | Aim. To investigate the link between insulin resistance (IR) and lipid transport system in patients with fasting normoglycemia. Material and methods. In 39 patients aged 2070 years, with fasting normoglycemia, the levels of lipids, apolipoproteins (apo), and IR parameters (insulin sensitivity index; ISI McAuley, HOMA-IR) were measured. Results. In patients with fasting normoglycemia and low ISI McAuley, atherogenic dyslipoproteinemia was observed: increased triglycerides, apo B, apo B/apo AI levels, reduced low-density lipoprotein particle size; disturbed high-density lipoprotein (HDL)-mediated cholesterol (CH) transport: reduced levels of free and esterified HDL-CH, phospholipids, apo A1, decreased HDL-CH particle loading, increased apo AII/apo AI concentration ratio. Conclusion. In patients with fasting normoglycemia, diagnosing latent carbohydrate metabolism disturbances, which are associated with lipid transport system abnormalities and potentially increased risk of coronary heart disease or Type 2 diabetes mellitus, provides an opportunity for early metabolic correction. |
| format | Article |
| id | doaj-art-eb0ab00910ea41ea97dea9a0b9751613 |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2007-10-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-eb0ab00910ea41ea97dea9a0b97516132025-08-20T03:57:09Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252007-10-016564691067Insulin resistance and lipid transport system in fasting normoglycemiaO. V. Alexandrovich0I. N. Ozerova1N. V. Perova2V. A. Metelskaya3A. M. Olferyev4G. N. Shchukina5State Research Center for Preventive Medicine, State Federal Agency for Health and Social DevelopmentState Research Center for Preventive Medicine, State Federal Agency for Health and Social DevelopmentState Research Center for Preventive Medicine, State Federal Agency for Health and Social DevelopmentState Research Center for Preventive Medicine, State Federal Agency for Health and Social DevelopmentState Research Center for Preventive Medicine, State Federal Agency for Health and Social DevelopmentMoscow State Medico-Stomatological University, MoscowAim. To investigate the link between insulin resistance (IR) and lipid transport system in patients with fasting normoglycemia. Material and methods. In 39 patients aged 2070 years, with fasting normoglycemia, the levels of lipids, apolipoproteins (apo), and IR parameters (insulin sensitivity index; ISI McAuley, HOMA-IR) were measured. Results. In patients with fasting normoglycemia and low ISI McAuley, atherogenic dyslipoproteinemia was observed: increased triglycerides, apo B, apo B/apo AI levels, reduced low-density lipoprotein particle size; disturbed high-density lipoprotein (HDL)-mediated cholesterol (CH) transport: reduced levels of free and esterified HDL-CH, phospholipids, apo A1, decreased HDL-CH particle loading, increased apo AII/apo AI concentration ratio. Conclusion. In patients with fasting normoglycemia, diagnosing latent carbohydrate metabolism disturbances, which are associated with lipid transport system abnormalities and potentially increased risk of coronary heart disease or Type 2 diabetes mellitus, provides an opportunity for early metabolic correction.https://cardiovascular.elpub.ru/jour/article/view/1357insulin resistancedyslipoproteinemiahdl lipid-protein componentsnormoglycemia |
| spellingShingle | O. V. Alexandrovich I. N. Ozerova N. V. Perova V. A. Metelskaya A. M. Olferyev G. N. Shchukina Insulin resistance and lipid transport system in fasting normoglycemia Кардиоваскулярная терапия и профилактика insulin resistance dyslipoproteinemia hdl lipid-protein components normoglycemia |
| title | Insulin resistance and lipid transport system in fasting normoglycemia |
| title_full | Insulin resistance and lipid transport system in fasting normoglycemia |
| title_fullStr | Insulin resistance and lipid transport system in fasting normoglycemia |
| title_full_unstemmed | Insulin resistance and lipid transport system in fasting normoglycemia |
| title_short | Insulin resistance and lipid transport system in fasting normoglycemia |
| title_sort | insulin resistance and lipid transport system in fasting normoglycemia |
| topic | insulin resistance dyslipoproteinemia hdl lipid-protein components normoglycemia |
| url | https://cardiovascular.elpub.ru/jour/article/view/1357 |
| work_keys_str_mv | AT ovalexandrovich insulinresistanceandlipidtransportsysteminfastingnormoglycemia AT inozerova insulinresistanceandlipidtransportsysteminfastingnormoglycemia AT nvperova insulinresistanceandlipidtransportsysteminfastingnormoglycemia AT vametelskaya insulinresistanceandlipidtransportsysteminfastingnormoglycemia AT amolferyev insulinresistanceandlipidtransportsysteminfastingnormoglycemia AT gnshchukina insulinresistanceandlipidtransportsysteminfastingnormoglycemia |