Association of triglyceride glucose-related obesity indices with sarcopenia among U.S. adults: a cross-sectional study from the National Health and Nutrition Examination Survey
Abstract The triglyceride glucose (TyG) index-related obesity indices have been proposed as reliable indicators of insulin resistance. This study aims to investigate the association between TyG index-related obesity indices and sarcopenia as well as their potential as a tool for screening sarcopenic...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-84278-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559701709389824 |
|---|---|
| author | Runtao Zhao Xinqiang Ji Fan Wang |
| author_facet | Runtao Zhao Xinqiang Ji Fan Wang |
| author_sort | Runtao Zhao |
| collection | DOAJ |
| description | Abstract The triglyceride glucose (TyG) index-related obesity indices have been proposed as reliable indicators of insulin resistance. This study aims to investigate the association between TyG index-related obesity indices and sarcopenia as well as their potential as a tool for screening sarcopenic patients. A cross-sectional study was conducted involving 7,161 participants aged 18 and above from the National Health and Nutrition Examination Survey. TyG index and TyG index-related obesity indices, including triglyceride glucose-body mass index (TyG-BMI), triglyceride glucose-waist circumference (TyG-WC), and triglyceride glucose-waist-to-height ratio (TyG-WHtR) were determined using standard formulas. The ratio of appendicular skeletal muscle mass to BMI were used to assess sarcopenia. The relationship between the TyG index as well as TyG index-related obesity indices and sarcopenia was investigated using restricted cubic spline analysis and multivariate logistic regression analysis. The diagnostic value of the TyG index and TyG index -related obesity indices for sarcopenia was compared using the receiver operating characteristic (ROC) curve. In the fully adjusted regression model, a positive correlation was observed between the TyG-WHtR index and sarcopenia (for each one-unit increase in TyG-WHtR index: OR = 3.57, 95% CI: 2.71–4.71, P < 0.001). Additionally, regression analyses demonstrated TyG-WHtR as a significant predictor of sarcopenia with the highest odds ratio, reaching 12.50 (95% CI: 6.13–25.70, P < 0.001) for the upper fourth quartile (Q4) compared to the first quartile, followed by followed by TyG-BMI (Q4: 3.34; 95% CI: 1.92–5.80, P < 0.001) and TyG-WC (Q4: 1.95; 95% CI: 1.04–3.68, P < 0.001). The RCS curve fitting analysis indicated a U-shaped relationship between TyG-WHtR and the diagnosis of sarcopenia, with an inflection point at 4.02. Furthermore, in the ROC analysis, the AUC for the diagnosis of sarcopenia was largest for TyG-WHtR (0.79, P < 0.001). The TyG ndex-related obesity indices, especially TyG-WHtR, have been shown to be more effective in identifying sarcopenia patients than TyG alone. |
| format | Article |
| id | doaj-art-eadce95797f14fd48281c13b4dcfbc7b |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-eadce95797f14fd48281c13b4dcfbc7b2025-01-05T12:19:42ZengNature PortfolioScientific Reports2045-23222025-01-0115111310.1038/s41598-024-84278-3Association of triglyceride glucose-related obesity indices with sarcopenia among U.S. adults: a cross-sectional study from the National Health and Nutrition Examination SurveyRuntao Zhao0Xinqiang Ji1Fan Wang2Department of Cardiology, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General HospitalDepartment of Cardiology, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General HospitalDepartment of Cardiology, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General HospitalAbstract The triglyceride glucose (TyG) index-related obesity indices have been proposed as reliable indicators of insulin resistance. This study aims to investigate the association between TyG index-related obesity indices and sarcopenia as well as their potential as a tool for screening sarcopenic patients. A cross-sectional study was conducted involving 7,161 participants aged 18 and above from the National Health and Nutrition Examination Survey. TyG index and TyG index-related obesity indices, including triglyceride glucose-body mass index (TyG-BMI), triglyceride glucose-waist circumference (TyG-WC), and triglyceride glucose-waist-to-height ratio (TyG-WHtR) were determined using standard formulas. The ratio of appendicular skeletal muscle mass to BMI were used to assess sarcopenia. The relationship between the TyG index as well as TyG index-related obesity indices and sarcopenia was investigated using restricted cubic spline analysis and multivariate logistic regression analysis. The diagnostic value of the TyG index and TyG index -related obesity indices for sarcopenia was compared using the receiver operating characteristic (ROC) curve. In the fully adjusted regression model, a positive correlation was observed between the TyG-WHtR index and sarcopenia (for each one-unit increase in TyG-WHtR index: OR = 3.57, 95% CI: 2.71–4.71, P < 0.001). Additionally, regression analyses demonstrated TyG-WHtR as a significant predictor of sarcopenia with the highest odds ratio, reaching 12.50 (95% CI: 6.13–25.70, P < 0.001) for the upper fourth quartile (Q4) compared to the first quartile, followed by followed by TyG-BMI (Q4: 3.34; 95% CI: 1.92–5.80, P < 0.001) and TyG-WC (Q4: 1.95; 95% CI: 1.04–3.68, P < 0.001). The RCS curve fitting analysis indicated a U-shaped relationship between TyG-WHtR and the diagnosis of sarcopenia, with an inflection point at 4.02. Furthermore, in the ROC analysis, the AUC for the diagnosis of sarcopenia was largest for TyG-WHtR (0.79, P < 0.001). The TyG ndex-related obesity indices, especially TyG-WHtR, have been shown to be more effective in identifying sarcopenia patients than TyG alone.https://doi.org/10.1038/s41598-024-84278-3SarcopeniaInsulin resistanceTriglyceride glucose indexTriglyceride glucose-related obesity indicesNational Health and Nutrition Examination Survey |
| spellingShingle | Runtao Zhao Xinqiang Ji Fan Wang Association of triglyceride glucose-related obesity indices with sarcopenia among U.S. adults: a cross-sectional study from the National Health and Nutrition Examination Survey Scientific Reports Sarcopenia Insulin resistance Triglyceride glucose index Triglyceride glucose-related obesity indices National Health and Nutrition Examination Survey |
| title | Association of triglyceride glucose-related obesity indices with sarcopenia among U.S. adults: a cross-sectional study from the National Health and Nutrition Examination Survey |
| title_full | Association of triglyceride glucose-related obesity indices with sarcopenia among U.S. adults: a cross-sectional study from the National Health and Nutrition Examination Survey |
| title_fullStr | Association of triglyceride glucose-related obesity indices with sarcopenia among U.S. adults: a cross-sectional study from the National Health and Nutrition Examination Survey |
| title_full_unstemmed | Association of triglyceride glucose-related obesity indices with sarcopenia among U.S. adults: a cross-sectional study from the National Health and Nutrition Examination Survey |
| title_short | Association of triglyceride glucose-related obesity indices with sarcopenia among U.S. adults: a cross-sectional study from the National Health and Nutrition Examination Survey |
| title_sort | association of triglyceride glucose related obesity indices with sarcopenia among u s adults a cross sectional study from the national health and nutrition examination survey |
| topic | Sarcopenia Insulin resistance Triglyceride glucose index Triglyceride glucose-related obesity indices National Health and Nutrition Examination Survey |
| url | https://doi.org/10.1038/s41598-024-84278-3 |
| work_keys_str_mv | AT runtaozhao associationoftriglycerideglucoserelatedobesityindiceswithsarcopeniaamongusadultsacrosssectionalstudyfromthenationalhealthandnutritionexaminationsurvey AT xinqiangji associationoftriglycerideglucoserelatedobesityindiceswithsarcopeniaamongusadultsacrosssectionalstudyfromthenationalhealthandnutritionexaminationsurvey AT fanwang associationoftriglycerideglucoserelatedobesityindiceswithsarcopeniaamongusadultsacrosssectionalstudyfromthenationalhealthandnutritionexaminationsurvey |