Platelet activation through CD62P and the formation of platelet–monocyte complexes are associated with the exacerbation of mucosal inflammation in patients with ulcerative colitis

Platelet activation through CD62P and the formation of platelet–monocyte complexes are associated with the exacerbation of mucosal inflammation in patients with ulcerative colitis

Abstract Ulcerative colitis (UC) is a refractory, chronic inflammatory bowel disease of unknown etiology. Although platelets are activated in UC, their relevance in pathophysiology remains unclear. We analyzed the correlation of platelet activation and platelet–monocyte complexes (PMCs) with severit...

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Bibliographic Details
Main Authors: Yasuki Sano, Takashi Tomiyama, Naoto Yagi, Yuka Ito, Yusuke Honzawa, Tomomitsu Tahara, Tsukasa Ikeura, Toshiro Fukui, Shinji Shimoda, Makoto Naganuma
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Ulcerative colitis
CD62P
Platelet–monocyte complexes
Mayo endoscopic subscore
CD16
Online Access:https://doi.org/10.1038/s41598-024-78462-8
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