Efficacy of a New Multivalent Vaccine for the Control of Bovine Respiratory Disease (BRD) in a Randomized Clinical Trial in Commercial Fattening Units
A new multivalent vaccine (DIVENCE<sup>®</sup>), containing live gE/tk double-gene-deleted BoHV-1, live-attenuated BRSV, inactivated PI3, and BVDV-1, and BVDV-2 recombinant proteins, has been designed to protect cattle against the main viral pathogens associated with bovine respiratory d...
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MDPI AG
2024-10-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/12/11/1233 |
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| author | Mariona Tapiolas Marta Gibert Carlos Montbrau Ester Taberner Marina Solé Héctor Santo Tomás Ainhoa Puig Ricard March |
| author_facet | Mariona Tapiolas Marta Gibert Carlos Montbrau Ester Taberner Marina Solé Héctor Santo Tomás Ainhoa Puig Ricard March |
| author_sort | Mariona Tapiolas |
| collection | DOAJ |
| description | A new multivalent vaccine (DIVENCE<sup>®</sup>), containing live gE/tk double-gene-deleted BoHV-1, live-attenuated BRSV, inactivated PI3, and BVDV-1, and BVDV-2 recombinant proteins, has been designed to protect cattle against the main viral pathogens associated with bovine respiratory disease (BRD). The aim of this study was to demonstrate the efficacy of DIVENCE<sup>®</sup> against BRD in field conditions. A total of 360 animals from three different farms were included in this study. Calves were randomly distributed to the vaccinated (<i>n</i> = 183; DIVENCE<sup>®</sup>) or control (<i>n</i> = 177; phosphate-buffered saline solution) group. All animals received two intramuscular doses (2 mL/dose) three weeks apart of the corresponding product. The entire fattening period (approximately 9 months) was monitored to assess the incidence, severity, and morbidity of BRD as well as administered treatments and growth performance. During this study, a BRSV outbreak was reported in one farm, where vaccinated animals had significantly (<i>p</i> < 0.02) lower morbidity (20.4%) and severity (score of 1.70) compared to the control group (53.70% and score of 2.11). Overall, vaccinated animals had a significantly lower number of cases (<i>p</i> < 0.001; 0.36 vs. 0.64 cases/calf), lower morbidity (<i>p</i> < 0.004; 26.78% vs. 41.24%), and lower antimicrobial treatments (<i>p</i> = 0.01; 33.3% vs. 57.4%) than control animals. Vaccinated animals presented significantly (<i>p</i> = 0.01) higher carcass weight than controls (6.58 kg). Vaccination with DIVENCE<sup>®</sup> at the beginning of the fattening period decreased the incidence and morbidity of BRD following a BRSV outbreak. Additionally, the overall incidence and morbidity of BRD throughout the entire fattening period were reduced across farms. Thus, DIVENCE<sup>®</sup> can improve economic outcomes in fattening units by reducing antibiotic treatments and enhancing performance. |
| format | Article |
| id | doaj-art-ea9f25ec9207457c87473ace3b2cd85c |
| institution | Kabale University |
| issn | 2076-393X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj-art-ea9f25ec9207457c87473ace3b2cd85c2024-11-26T18:24:32ZengMDPI AGVaccines2076-393X2024-10-011211123310.3390/vaccines12111233Efficacy of a New Multivalent Vaccine for the Control of Bovine Respiratory Disease (BRD) in a Randomized Clinical Trial in Commercial Fattening UnitsMariona Tapiolas0Marta Gibert1Carlos Montbrau2Ester Taberner3Marina Solé4Héctor Santo Tomás5Ainhoa Puig6Ricard March7Hipra Scientific S.L.U., Avda. La Selva 135, 17170 Amer, SpainHipra Scientific S.L.U., Avda. La Selva 135, 17170 Amer, SpainHipra Scientific S.L.U., Avda. La Selva 135, 17170 Amer, SpainHipra Scientific S.L.U., Avda. La Selva 135, 17170 Amer, SpainHIPRA S.A., Avinguda La Selva 135, 1710 Amer, SpainHIPRA S.A., Avinguda La Selva 135, 1710 Amer, SpainHipra Scientific S.L.U., Avda. La Selva 135, 17170 Amer, SpainHipra Scientific S.L.U., Avda. La Selva 135, 17170 Amer, SpainA new multivalent vaccine (DIVENCE<sup>®</sup>), containing live gE/tk double-gene-deleted BoHV-1, live-attenuated BRSV, inactivated PI3, and BVDV-1, and BVDV-2 recombinant proteins, has been designed to protect cattle against the main viral pathogens associated with bovine respiratory disease (BRD). The aim of this study was to demonstrate the efficacy of DIVENCE<sup>®</sup> against BRD in field conditions. A total of 360 animals from three different farms were included in this study. Calves were randomly distributed to the vaccinated (<i>n</i> = 183; DIVENCE<sup>®</sup>) or control (<i>n</i> = 177; phosphate-buffered saline solution) group. All animals received two intramuscular doses (2 mL/dose) three weeks apart of the corresponding product. The entire fattening period (approximately 9 months) was monitored to assess the incidence, severity, and morbidity of BRD as well as administered treatments and growth performance. During this study, a BRSV outbreak was reported in one farm, where vaccinated animals had significantly (<i>p</i> < 0.02) lower morbidity (20.4%) and severity (score of 1.70) compared to the control group (53.70% and score of 2.11). Overall, vaccinated animals had a significantly lower number of cases (<i>p</i> < 0.001; 0.36 vs. 0.64 cases/calf), lower morbidity (<i>p</i> < 0.004; 26.78% vs. 41.24%), and lower antimicrobial treatments (<i>p</i> = 0.01; 33.3% vs. 57.4%) than control animals. Vaccinated animals presented significantly (<i>p</i> = 0.01) higher carcass weight than controls (6.58 kg). Vaccination with DIVENCE<sup>®</sup> at the beginning of the fattening period decreased the incidence and morbidity of BRD following a BRSV outbreak. Additionally, the overall incidence and morbidity of BRD throughout the entire fattening period were reduced across farms. Thus, DIVENCE<sup>®</sup> can improve economic outcomes in fattening units by reducing antibiotic treatments and enhancing performance.https://www.mdpi.com/2076-393X/12/11/1233bovine respiratory disease (BRD)morbidityincidenceantimicrobialsfield conditionsperformance |
| spellingShingle | Mariona Tapiolas Marta Gibert Carlos Montbrau Ester Taberner Marina Solé Héctor Santo Tomás Ainhoa Puig Ricard March Efficacy of a New Multivalent Vaccine for the Control of Bovine Respiratory Disease (BRD) in a Randomized Clinical Trial in Commercial Fattening Units Vaccines bovine respiratory disease (BRD) morbidity incidence antimicrobials field conditions performance |
| title | Efficacy of a New Multivalent Vaccine for the Control of Bovine Respiratory Disease (BRD) in a Randomized Clinical Trial in Commercial Fattening Units |
| title_full | Efficacy of a New Multivalent Vaccine for the Control of Bovine Respiratory Disease (BRD) in a Randomized Clinical Trial in Commercial Fattening Units |
| title_fullStr | Efficacy of a New Multivalent Vaccine for the Control of Bovine Respiratory Disease (BRD) in a Randomized Clinical Trial in Commercial Fattening Units |
| title_full_unstemmed | Efficacy of a New Multivalent Vaccine for the Control of Bovine Respiratory Disease (BRD) in a Randomized Clinical Trial in Commercial Fattening Units |
| title_short | Efficacy of a New Multivalent Vaccine for the Control of Bovine Respiratory Disease (BRD) in a Randomized Clinical Trial in Commercial Fattening Units |
| title_sort | efficacy of a new multivalent vaccine for the control of bovine respiratory disease brd in a randomized clinical trial in commercial fattening units |
| topic | bovine respiratory disease (BRD) morbidity incidence antimicrobials field conditions performance |
| url | https://www.mdpi.com/2076-393X/12/11/1233 |
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