TORC2 inhibition triggers yeast chromosome fragmentation through misregulated Base Excision Repair of clustered oxidation events

TORC2 inhibition triggers yeast chromosome fragmentation through misregulated Base Excision Repair of clustered oxidation events

Abstract Combinational therapies provoking cell death are of major interest in oncology. Combining TORC2 kinase inhibition with the radiomimetic drug Zeocin results in a rapid accumulation of double-strand breaks (DSB) in the budding yeast genome. This lethal Yeast Chromosome Shattering (YCS) requir...

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Bibliographic Details
Main Authors: Kenji Shimada, Cleo V. D. Tarashev, Stephanie Bregenhorn, Christian B. Gerhold, Barbara van Loon, Gregory Roth, Verena Hurst, Josef Jiricny, Stephen B. Helliwell, Susan M. Gasser
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54142-z
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