Parallel Networks to Predict TIMP and Protease Cell Activity of Nucleus Pulposus Cells Exposed and Not Exposed to Pro‐Inflammatory Cytokines

Parallel Networks to Predict TIMP and Protease Cell Activity of Nucleus Pulposus Cells Exposed and Not Exposed to Pro‐Inflammatory Cytokines

ABSTRACT Background Intervertebral disc (IVD) degeneration is characterized by a disruption of the balance between anabolic and catabolic cellular processes. Within the nucleus pulposus (NP), this involves increased levels of the pro‐inflammatory cytokines interleukin 1beta (IL1B) and tumor necrosis...

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Bibliographic Details
Main Authors: L. Baumgartner, S. Witta, J. Noailly
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:JOR Spine
Subjects:
cell nutrition
intervertebral disc
mechanotransduction
mRNA expression
network modeling
parallel networks
Online Access:https://doi.org/10.1002/jsp2.70051
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https://doi.org/10.1002/jsp2.70051

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