A comparative study of cognitive impairment in sporadic and familial cases of multiple sclerosis
Abstract Genetics plays a significant role in Multiple Sclerosis (MS), with approximately 12.6% of cases occurring in familial form. While previous studies have demonstrated differences in disease progression and MRI findings between familial and sporadic MS, there has been no comparison of cognitiv...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-84779-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559629407977472 |
|---|---|
| author | Vida Niakosari Ali Namjoo-Moghadam Ahmad Ali Abin Maryam Poursadeghfard Sana Hashemi |
| author_facet | Vida Niakosari Ali Namjoo-Moghadam Ahmad Ali Abin Maryam Poursadeghfard Sana Hashemi |
| author_sort | Vida Niakosari |
| collection | DOAJ |
| description | Abstract Genetics plays a significant role in Multiple Sclerosis (MS), with approximately 12.6% of cases occurring in familial form. While previous studies have demonstrated differences in disease progression and MRI findings between familial and sporadic MS, there has been no comparison of cognitive impairment between them. In this study, we evaluated cognitive performance among patients with sporadic and familial MS, along with a healthy control group. A total of 130 individuals, matched for age, sex, and education, were recruited for each group. The mean age of participants was 37.8 ± 9.8 years, and 77.6% of them were female. Cognitive performance was assessed using the Brief International Cognitive Assessment for MS (BICAMS) across the three groups. Both familial and sporadic MS patients showed poorer cognitive performance in the Symbol Digit Modalities Test (SDMT) (Familial: 46.96 ± 12.59, Sporadic: 45.88 ± 14.13, Normal: 56.48 ± 11.89), California Verbal Learning Test (CVLT) (Familial: 66.90 ± 14.01, Sporadic: 68.19 ± 16.49, Normal: 75.18 ± 13.02), and the Brief Visuospatial Memory Test-Revised (BVMT-R) (Familial: 24 (12), Sporadic: 24 (12), Normal: 35 (4)) compared to healthy controls. Meanwhile, no significant differences in cognitive impairment were observed between the familial and sporadic MS groups in the SDMT (p = 1.000), CVLT (p = 0.775), and BVMT-R (p = 0.733). Furthermore, this study found significant relationships between education, depression, age, and sex with different aspects of cognitive performance in MS. Overall, both familial and sporadic MS patients demonstrated similar levels of cognitive impairment. |
| format | Article |
| id | doaj-art-ea83e1a212e54759b09072cf1de36526 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-ea83e1a212e54759b09072cf1de365262025-01-05T12:20:58ZengNature PortfolioScientific Reports2045-23222025-01-011511710.1038/s41598-024-84779-1A comparative study of cognitive impairment in sporadic and familial cases of multiple sclerosisVida Niakosari0Ali Namjoo-Moghadam1Ahmad Ali Abin2Maryam Poursadeghfard3Sana Hashemi4Faculty of Computer Science and Engineering, Shahid Beheshti UniversityClinical Neurology Research Center, Shiraz University of Medical SciencesFaculty of Computer Science and Engineering, Shahid Beheshti UniversityClinical Neurology Research Center, Shiraz University of Medical SciencesFaculty of Computer Science and Engineering, Shahid Beheshti UniversityAbstract Genetics plays a significant role in Multiple Sclerosis (MS), with approximately 12.6% of cases occurring in familial form. While previous studies have demonstrated differences in disease progression and MRI findings between familial and sporadic MS, there has been no comparison of cognitive impairment between them. In this study, we evaluated cognitive performance among patients with sporadic and familial MS, along with a healthy control group. A total of 130 individuals, matched for age, sex, and education, were recruited for each group. The mean age of participants was 37.8 ± 9.8 years, and 77.6% of them were female. Cognitive performance was assessed using the Brief International Cognitive Assessment for MS (BICAMS) across the three groups. Both familial and sporadic MS patients showed poorer cognitive performance in the Symbol Digit Modalities Test (SDMT) (Familial: 46.96 ± 12.59, Sporadic: 45.88 ± 14.13, Normal: 56.48 ± 11.89), California Verbal Learning Test (CVLT) (Familial: 66.90 ± 14.01, Sporadic: 68.19 ± 16.49, Normal: 75.18 ± 13.02), and the Brief Visuospatial Memory Test-Revised (BVMT-R) (Familial: 24 (12), Sporadic: 24 (12), Normal: 35 (4)) compared to healthy controls. Meanwhile, no significant differences in cognitive impairment were observed between the familial and sporadic MS groups in the SDMT (p = 1.000), CVLT (p = 0.775), and BVMT-R (p = 0.733). Furthermore, this study found significant relationships between education, depression, age, and sex with different aspects of cognitive performance in MS. Overall, both familial and sporadic MS patients demonstrated similar levels of cognitive impairment.https://doi.org/10.1038/s41598-024-84779-1Multiple sclerosisFamilial MSCognitive impairmentBICAMS |
| spellingShingle | Vida Niakosari Ali Namjoo-Moghadam Ahmad Ali Abin Maryam Poursadeghfard Sana Hashemi A comparative study of cognitive impairment in sporadic and familial cases of multiple sclerosis Scientific Reports Multiple sclerosis Familial MS Cognitive impairment BICAMS |
| title | A comparative study of cognitive impairment in sporadic and familial cases of multiple sclerosis |
| title_full | A comparative study of cognitive impairment in sporadic and familial cases of multiple sclerosis |
| title_fullStr | A comparative study of cognitive impairment in sporadic and familial cases of multiple sclerosis |
| title_full_unstemmed | A comparative study of cognitive impairment in sporadic and familial cases of multiple sclerosis |
| title_short | A comparative study of cognitive impairment in sporadic and familial cases of multiple sclerosis |
| title_sort | comparative study of cognitive impairment in sporadic and familial cases of multiple sclerosis |
| topic | Multiple sclerosis Familial MS Cognitive impairment BICAMS |
| url | https://doi.org/10.1038/s41598-024-84779-1 |
| work_keys_str_mv | AT vidaniakosari acomparativestudyofcognitiveimpairmentinsporadicandfamilialcasesofmultiplesclerosis AT alinamjoomoghadam acomparativestudyofcognitiveimpairmentinsporadicandfamilialcasesofmultiplesclerosis AT ahmadaliabin acomparativestudyofcognitiveimpairmentinsporadicandfamilialcasesofmultiplesclerosis AT maryampoursadeghfard acomparativestudyofcognitiveimpairmentinsporadicandfamilialcasesofmultiplesclerosis AT sanahashemi acomparativestudyofcognitiveimpairmentinsporadicandfamilialcasesofmultiplesclerosis AT vidaniakosari comparativestudyofcognitiveimpairmentinsporadicandfamilialcasesofmultiplesclerosis AT alinamjoomoghadam comparativestudyofcognitiveimpairmentinsporadicandfamilialcasesofmultiplesclerosis AT ahmadaliabin comparativestudyofcognitiveimpairmentinsporadicandfamilialcasesofmultiplesclerosis AT maryampoursadeghfard comparativestudyofcognitiveimpairmentinsporadicandfamilialcasesofmultiplesclerosis AT sanahashemi comparativestudyofcognitiveimpairmentinsporadicandfamilialcasesofmultiplesclerosis |