Hazel leaf polyphenols ameliorate hyperuricemia-induced renal fibrosis through regulating uric acid metabolism and inhibiting ferroptosis via the Nrf2/GPX4 signaling axis

Hazel leaf polyphenols ameliorate hyperuricemia-induced renal fibrosis through regulating uric acid metabolism and inhibiting ferroptosis via the Nrf2/GPX4 signaling axis

Hazel leaves, a by-product of hazelnut, have been consumed for health care in some countries and regions for hundreds of years. Based on our previous results, this study further investigated the protective effects of hazel leaf polyphenols (HP) on renal fibrosis induced by hyperuricemia in mice. Res...

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Bibliographic Details
Main Authors: Xinhe Wang, Xiaowen Li, Jiarui Zhao, Zhi Lin, Jun Li, Xinyi Xu, Xinrui Zhou, Yuchen Wang, Guangfu Lv, He Lin, Zhe Lin
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Journal of Functional Foods
Subjects:
Hazel leaf polyphenols
Hyperuricemia
Renal fibrosis
Oxidative stress
Ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464624005826
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