Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypes

Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypes

Abstract Background Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), and Parkinson’s disease dementia (PDD) collectively represent the majority of dementia cases worldwide. While these subtypes share clinical, genetic, and pathological features, their transcriptomic similarities and differ...

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Main Authors: Sook-Yoong Chia, Mengwei Li, Zhihong Li, Haitao Tu, Jolene Wei Ling Lee, Lifeng Qiu, Jingjing Ling, Richard Reynolds, Salvatore Albani, Eng-King Tan, Adeline Su Lyn Ng, Jinmiao Chen, Li Zeng
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Genome Medicine
Subjects:
Alzheimer’s disease
Parkinson’s disease dementia
Dementia with Lewy bodies
Single-nucleus RNA-sequencing
Microglia
Macrophage scavenger receptor 1 (MSR1)
Online Access:https://doi.org/10.1186/s13073-025-01519-4
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https://doi.org/10.1186/s13073-025-01519-4

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