Iron metabolism in rheumatic diseases
Iron is a crucial element for living organism in terms of oxygen transport, hematopoiesis, enzymatic activity, mitochondrial respiratory chain function and also immune system function. The human being has evolved a mechanism to regulate body iron. In some rheumatic diseases such as rheumatoid arthri...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Journal of Translational Autoimmunity |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589909025000024 |
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| author | Aliakbar Givian Amin Azizan Ahmadreza Jamshidi Mahdi Mahmoudi Elham Farhadi |
| author_facet | Aliakbar Givian Amin Azizan Ahmadreza Jamshidi Mahdi Mahmoudi Elham Farhadi |
| author_sort | Aliakbar Givian |
| collection | DOAJ |
| description | Iron is a crucial element for living organism in terms of oxygen transport, hematopoiesis, enzymatic activity, mitochondrial respiratory chain function and also immune system function. The human being has evolved a mechanism to regulate body iron. In some rheumatic diseases such as rheumatoid arthritis (RA), systemic lupus erythematous (SLE), systemic sclerosis (SSc), ankylosing spondylitis (AS), and gout, this balanced iron regulation is impaired. Altered iron homeostasis can contribute to disease progression through ROS production, fibrosis, inflammation, abnormal bone homeostasis, NETosis and cell senescence. In this review, we have focused on the iron metabolism in rheumatic disease and its role in disease progression. |
| format | Article |
| id | doaj-art-ea64cfc82eb5408fb2fdc12f563366d6 |
| institution | Kabale University |
| issn | 2589-9090 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Translational Autoimmunity |
| spelling | doaj-art-ea64cfc82eb5408fb2fdc12f563366d62025-01-09T06:14:27ZengElsevierJournal of Translational Autoimmunity2589-90902025-06-0110100267Iron metabolism in rheumatic diseasesAliakbar Givian0Amin Azizan1Ahmadreza Jamshidi2Mahdi Mahmoudi3Elham Farhadi4Rheumatology Research Center, Tehran University of Medical Science, Tehran, Iran; Department of Immunology, School of Medicine, Semnan University of Medical Science, Semnan, IranRheumatology Research Center, Tehran University of Medical Science, Tehran, Iran; Research Center for Chronic Inflammatory Diseases, Tehran University of Medical Sciences, Tehran, IranRheumatology Research Center, Tehran University of Medical Science, Tehran, IranRheumatology Research Center, Tehran University of Medical Science, Tehran, Iran; Research Center for Chronic Inflammatory Diseases, Tehran University of Medical Sciences, Tehran, Iran; Corresponding author. Rheumatology Research Center, Shariati Hospital, Kargar Ave, Tehran, Iran.Rheumatology Research Center, Tehran University of Medical Science, Tehran, Iran; Research Center for Chronic Inflammatory Diseases, Tehran University of Medical Sciences, Tehran, Iran; Corresponding author. Rheumatology Research Center, Shariati Hospital, Kargar Ave, Tehran, Iran.Iron is a crucial element for living organism in terms of oxygen transport, hematopoiesis, enzymatic activity, mitochondrial respiratory chain function and also immune system function. The human being has evolved a mechanism to regulate body iron. In some rheumatic diseases such as rheumatoid arthritis (RA), systemic lupus erythematous (SLE), systemic sclerosis (SSc), ankylosing spondylitis (AS), and gout, this balanced iron regulation is impaired. Altered iron homeostasis can contribute to disease progression through ROS production, fibrosis, inflammation, abnormal bone homeostasis, NETosis and cell senescence. In this review, we have focused on the iron metabolism in rheumatic disease and its role in disease progression.http://www.sciencedirect.com/science/article/pii/S2589909025000024IronRheumatic diseasesReactive oxygen species (ROSs)Immune system |
| spellingShingle | Aliakbar Givian Amin Azizan Ahmadreza Jamshidi Mahdi Mahmoudi Elham Farhadi Iron metabolism in rheumatic diseases Journal of Translational Autoimmunity Iron Rheumatic diseases Reactive oxygen species (ROSs) Immune system |
| title | Iron metabolism in rheumatic diseases |
| title_full | Iron metabolism in rheumatic diseases |
| title_fullStr | Iron metabolism in rheumatic diseases |
| title_full_unstemmed | Iron metabolism in rheumatic diseases |
| title_short | Iron metabolism in rheumatic diseases |
| title_sort | iron metabolism in rheumatic diseases |
| topic | Iron Rheumatic diseases Reactive oxygen species (ROSs) Immune system |
| url | http://www.sciencedirect.com/science/article/pii/S2589909025000024 |
| work_keys_str_mv | AT aliakbargivian ironmetabolisminrheumaticdiseases AT aminazizan ironmetabolisminrheumaticdiseases AT ahmadrezajamshidi ironmetabolisminrheumaticdiseases AT mahdimahmoudi ironmetabolisminrheumaticdiseases AT elhamfarhadi ironmetabolisminrheumaticdiseases |