Dynamic PAH-Related Changes: A Dataset of tRNA-Derived Small RNA Transcriptome Across Multiple Organs
Abstract Pulmonary arterial hypertension (PAH) is a severe cardiopulmonary disease characterized by elevated pulmonary artery pressure and cardiac dysfunction, often leading to heart failure and even death. Despite the complexity of its mechanisms, the molecular basis of PAH remains unclear. tRNA-de...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-11-01
|
| Series: | Scientific Data |
| Online Access: | https://doi.org/10.1038/s41597-024-04115-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846158849164181504 |
|---|---|
| author | Yusi Chen Yi Tang Tengteng Zhu Fang Li Jun Luo Jingyuan Chen Yingjie Tan Tianyu Wang Jianqiang Peng Gang Jiang Jiang Li |
| author_facet | Yusi Chen Yi Tang Tengteng Zhu Fang Li Jun Luo Jingyuan Chen Yingjie Tan Tianyu Wang Jianqiang Peng Gang Jiang Jiang Li |
| author_sort | Yusi Chen |
| collection | DOAJ |
| description | Abstract Pulmonary arterial hypertension (PAH) is a severe cardiopulmonary disease characterized by elevated pulmonary artery pressure and cardiac dysfunction, often leading to heart failure and even death. Despite the complexity of its mechanisms, the molecular basis of PAH remains unclear. tRNA-derived small RNAs (tsRNAs) are noncoding RNAs that play regulatory roles in various diseases. We collected plasma samples from PAH patients and healthy controls for small RNA microarray, and we established a monocrotaline-induced PAH rat model to collect right ventricular and lung tissues for tsRNA sequencing. Our analysis revealed 2,716 unique tsRNAs in human plasma and 4,733 in rat tissues, with a 7.84% overlap. Additionally, 204 tsRNAs were highly conserved across plasma, lung tissue, and right ventricle samples. The reproducibility of the expression profiles was confirmed through Pearson correlation and principal component analysis. KEGG pathway enrichment analysis indicated that tsRNAs are involved in key pathways, such as the MAPK and cancer signalling pathways. These datasets offer valuable insights for researching the epigenetic mechanisms underlying PAH and potential therapeutic targets. |
| format | Article |
| id | doaj-art-ea59cdee80da4b5fb5c18e4a8c896c14 |
| institution | Kabale University |
| issn | 2052-4463 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Data |
| spelling | doaj-art-ea59cdee80da4b5fb5c18e4a8c896c142024-11-24T12:10:01ZengNature PortfolioScientific Data2052-44632024-11-011111710.1038/s41597-024-04115-0Dynamic PAH-Related Changes: A Dataset of tRNA-Derived Small RNA Transcriptome Across Multiple OrgansYusi Chen0Yi Tang1Tengteng Zhu2Fang Li3Jun Luo4Jingyuan Chen5Yingjie Tan6Tianyu Wang7Jianqiang Peng8Gang Jiang9Jiang Li10Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South UniversityDepartment of Cardiology, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Normal UniversityDepartment of Cardiology, The First Affiliated Hospital of Shandong First Medical University(Shandong Provincial Qianfoshan Hospital)Department of Radiology and Imaging, Zhuzhou Central Hospital of Central South UniversityDepartment of Cardiovascular Medicine, The Second Xiangya Hospital of Central South UniversityDepartment of Cardiovascular Medicine, The Second Xiangya Hospital of Central South UniversityDepartment of Cardiovascular Medicine, The Second Xiangya Hospital of Central South UniversityDepartment of Cardiovascular Medicine, The Second Xiangya Hospital of Central South UniversityDepartment of Cardiology, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Normal UniversityDepartment of Respiratory Medicine Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University)Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South UniversityAbstract Pulmonary arterial hypertension (PAH) is a severe cardiopulmonary disease characterized by elevated pulmonary artery pressure and cardiac dysfunction, often leading to heart failure and even death. Despite the complexity of its mechanisms, the molecular basis of PAH remains unclear. tRNA-derived small RNAs (tsRNAs) are noncoding RNAs that play regulatory roles in various diseases. We collected plasma samples from PAH patients and healthy controls for small RNA microarray, and we established a monocrotaline-induced PAH rat model to collect right ventricular and lung tissues for tsRNA sequencing. Our analysis revealed 2,716 unique tsRNAs in human plasma and 4,733 in rat tissues, with a 7.84% overlap. Additionally, 204 tsRNAs were highly conserved across plasma, lung tissue, and right ventricle samples. The reproducibility of the expression profiles was confirmed through Pearson correlation and principal component analysis. KEGG pathway enrichment analysis indicated that tsRNAs are involved in key pathways, such as the MAPK and cancer signalling pathways. These datasets offer valuable insights for researching the epigenetic mechanisms underlying PAH and potential therapeutic targets.https://doi.org/10.1038/s41597-024-04115-0 |
| spellingShingle | Yusi Chen Yi Tang Tengteng Zhu Fang Li Jun Luo Jingyuan Chen Yingjie Tan Tianyu Wang Jianqiang Peng Gang Jiang Jiang Li Dynamic PAH-Related Changes: A Dataset of tRNA-Derived Small RNA Transcriptome Across Multiple Organs Scientific Data |
| title | Dynamic PAH-Related Changes: A Dataset of tRNA-Derived Small RNA Transcriptome Across Multiple Organs |
| title_full | Dynamic PAH-Related Changes: A Dataset of tRNA-Derived Small RNA Transcriptome Across Multiple Organs |
| title_fullStr | Dynamic PAH-Related Changes: A Dataset of tRNA-Derived Small RNA Transcriptome Across Multiple Organs |
| title_full_unstemmed | Dynamic PAH-Related Changes: A Dataset of tRNA-Derived Small RNA Transcriptome Across Multiple Organs |
| title_short | Dynamic PAH-Related Changes: A Dataset of tRNA-Derived Small RNA Transcriptome Across Multiple Organs |
| title_sort | dynamic pah related changes a dataset of trna derived small rna transcriptome across multiple organs |
| url | https://doi.org/10.1038/s41597-024-04115-0 |
| work_keys_str_mv | AT yusichen dynamicpahrelatedchangesadatasetoftrnaderivedsmallrnatranscriptomeacrossmultipleorgans AT yitang dynamicpahrelatedchangesadatasetoftrnaderivedsmallrnatranscriptomeacrossmultipleorgans AT tengtengzhu dynamicpahrelatedchangesadatasetoftrnaderivedsmallrnatranscriptomeacrossmultipleorgans AT fangli dynamicpahrelatedchangesadatasetoftrnaderivedsmallrnatranscriptomeacrossmultipleorgans AT junluo dynamicpahrelatedchangesadatasetoftrnaderivedsmallrnatranscriptomeacrossmultipleorgans AT jingyuanchen dynamicpahrelatedchangesadatasetoftrnaderivedsmallrnatranscriptomeacrossmultipleorgans AT yingjietan dynamicpahrelatedchangesadatasetoftrnaderivedsmallrnatranscriptomeacrossmultipleorgans AT tianyuwang dynamicpahrelatedchangesadatasetoftrnaderivedsmallrnatranscriptomeacrossmultipleorgans AT jianqiangpeng dynamicpahrelatedchangesadatasetoftrnaderivedsmallrnatranscriptomeacrossmultipleorgans AT gangjiang dynamicpahrelatedchangesadatasetoftrnaderivedsmallrnatranscriptomeacrossmultipleorgans AT jiangli dynamicpahrelatedchangesadatasetoftrnaderivedsmallrnatranscriptomeacrossmultipleorgans |