Factors associated with prolonged viral detection in asymptomatic and mildly symptomatic patients with SARS-CoV-2 infection
Introduction: Data on the clinical course and duration of viral RNA detection in patients with mild or asymptomatic coronavirus disease 2019 are limited. Methodology: In this retrospective analysis, clinical characteristics and serial real-time reverse transcriptase-polymerase chain reaction (RT...
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The Journal of Infection in Developing Countries
2022-02-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/15072 |
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| author | Yong Hoon Lee Chae Moon Hong Taek Hoo Lee Yoon Jin Hwang Dae Hyun Kim Jaetae Lee |
| author_facet | Yong Hoon Lee Chae Moon Hong Taek Hoo Lee Yoon Jin Hwang Dae Hyun Kim Jaetae Lee |
| author_sort | Yong Hoon Lee |
| collection | DOAJ |
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Introduction: Data on the clinical course and duration of viral RNA detection in patients with mild or asymptomatic coronavirus disease 2019 are limited.
Methodology: In this retrospective analysis, clinical characteristics and serial real-time reverse transcriptase-polymerase chain reaction (RT-PCR) results were reviewed in a cohort of 1186 asymptomatic and mildly symptomatic coronavirus disease 2019 patients in South Korea. Factors associated with prolonged duration of RT-PCR positivity for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) were also evaluated. Patients with two consecutive negative RT-PCR tests ≥ 24 hours apart were considered to be in virologic remission and discharged.
Results: The average virologic remission period, defined as the number of days from diagnosis to virologic remission, was 22.0 ± 9.7 days; patients with longer than 30 days accounted for 21.2% (251/1186) of the population. Patients who took longer than 30 days to achieve virologic remission had a higher frequency of overall symptoms (p < 0.001) and respiratory symptoms (p < 0.001). In multivariate analysis using Cox-proportional hazard regression, it was confirmed that respiratory symptoms (hazard ratio [HR], 0.7372; 95% confidence interval [CI], 0.6540-0.8311) and gastrointestinal symptoms (HR, 0.8213; 95% CI, 0.6970-0.9679) were independent factors associated with prolonged virologic remission. Age and co-morbidity such as diabetes and hypertension were not associated with the prolonged RT-PCR positivity.
Conclusions: A considerable percentage of asymptomatic and mildly symptomatic patients with coronavirus disease 2019 showed prolonged RT-PCR positivity for SARS-CoV-2; which was independently associated with the presence of symptoms, but not with age and co-morbidity.
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| format | Article |
| id | doaj-art-ea55e9daa9c744ccaa18d17fa92c3df9 |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2022-02-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-ea55e9daa9c744ccaa18d17fa92c3df92025-08-20T03:52:42ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802022-02-01160210.3855/jidc.15072Factors associated with prolonged viral detection in asymptomatic and mildly symptomatic patients with SARS-CoV-2 infectionYong Hoon Lee0Chae Moon Hong1Taek Hoo Lee2Yoon Jin Hwang3Dae Hyun Kim4Jaetae Lee5Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South KoreaDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, South KoreaDepartment of Obstetrics and Gynecology, School of Medicine, Kyungpook National University, Daegu, South KoreaDepartment of Surgery, School of Medicine, Kyungpook National University, Daegu, South KoreaDepartment of Family Medicine, Keimyung University Dongsan Medical Center, Daegu, South KoreaDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea Introduction: Data on the clinical course and duration of viral RNA detection in patients with mild or asymptomatic coronavirus disease 2019 are limited. Methodology: In this retrospective analysis, clinical characteristics and serial real-time reverse transcriptase-polymerase chain reaction (RT-PCR) results were reviewed in a cohort of 1186 asymptomatic and mildly symptomatic coronavirus disease 2019 patients in South Korea. Factors associated with prolonged duration of RT-PCR positivity for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) were also evaluated. Patients with two consecutive negative RT-PCR tests ≥ 24 hours apart were considered to be in virologic remission and discharged. Results: The average virologic remission period, defined as the number of days from diagnosis to virologic remission, was 22.0 ± 9.7 days; patients with longer than 30 days accounted for 21.2% (251/1186) of the population. Patients who took longer than 30 days to achieve virologic remission had a higher frequency of overall symptoms (p < 0.001) and respiratory symptoms (p < 0.001). In multivariate analysis using Cox-proportional hazard regression, it was confirmed that respiratory symptoms (hazard ratio [HR], 0.7372; 95% confidence interval [CI], 0.6540-0.8311) and gastrointestinal symptoms (HR, 0.8213; 95% CI, 0.6970-0.9679) were independent factors associated with prolonged virologic remission. Age and co-morbidity such as diabetes and hypertension were not associated with the prolonged RT-PCR positivity. Conclusions: A considerable percentage of asymptomatic and mildly symptomatic patients with coronavirus disease 2019 showed prolonged RT-PCR positivity for SARS-CoV-2; which was independently associated with the presence of symptoms, but not with age and co-morbidity. https://jidc.org/index.php/journal/article/view/15072SARS-CoV-2COVID-19Community Treatment CenterRT-PCRSymptomsComorbidity |
| spellingShingle | Yong Hoon Lee Chae Moon Hong Taek Hoo Lee Yoon Jin Hwang Dae Hyun Kim Jaetae Lee Factors associated with prolonged viral detection in asymptomatic and mildly symptomatic patients with SARS-CoV-2 infection Journal of Infection in Developing Countries SARS-CoV-2 COVID-19 Community Treatment Center RT-PCR Symptoms Comorbidity |
| title | Factors associated with prolonged viral detection in asymptomatic and mildly symptomatic patients with SARS-CoV-2 infection |
| title_full | Factors associated with prolonged viral detection in asymptomatic and mildly symptomatic patients with SARS-CoV-2 infection |
| title_fullStr | Factors associated with prolonged viral detection in asymptomatic and mildly symptomatic patients with SARS-CoV-2 infection |
| title_full_unstemmed | Factors associated with prolonged viral detection in asymptomatic and mildly symptomatic patients with SARS-CoV-2 infection |
| title_short | Factors associated with prolonged viral detection in asymptomatic and mildly symptomatic patients with SARS-CoV-2 infection |
| title_sort | factors associated with prolonged viral detection in asymptomatic and mildly symptomatic patients with sars cov 2 infection |
| topic | SARS-CoV-2 COVID-19 Community Treatment Center RT-PCR Symptoms Comorbidity |
| url | https://jidc.org/index.php/journal/article/view/15072 |
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